Book Section

© 2015 by John Wiley & Sons, Ltd. All rights reserved. The mammalian sirtuins are a family of seven NAD+-dependent deacetylase enzymes that regulate a wide range of hepatic functions. Altered sirtuin expression in model organisms results in pleiotropic hepatic dysfunction. Furthermore, altered sirtuin expression in humans is associated with hepatic diseases including NAFLD, NASH, and HCC. In this chapter, we review the known biology of the seven sirtuins and the areas of emerging interest in this exciting field.

Full Text

Duke Authors

Cited Authors

  • Huynh, FK; Mcdonnell, E; Anderson, KA; Hirschey, MD

Published Date

  • September 28, 2015

Book Title

  • Signaling Pathways in Liver Diseases: Third Edition

Start / End Page

  • 374 - 384

International Standard Book Number 13 (ISBN-13)

  • 9781118663394

Digital Object Identifier (DOI)

  • 10.1002/9781118663387.ch27

Citation Source

  • Scopus