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Dalantercept

Publication ,  Journal Article
Hector-Greene, ME; Blobe, GC
Published in: Drugs of the Future
October 1, 2015

The TGF-b superfamily receptor activin receptor-like kinase 1 (ALK-1) has essential roles in regulating angiogenesis during development and homeostasis, as well as pathophysiological tumor angiogenesis. Dalantercept is a soluble chimeric protein composed of the ALK-1 extracellular domain fused to the human Fc domain. Dalantercept acts as a ligand trap to prevent the activation of endogenous ALK-1 by bone morphogenetic proteins 9/10. In preclinical models, dalantercept inhibits tumor growth and enhances the efficacy of cytotoxic chemotherapy. In early clinical development, dalantercept as a single agent has had a promising disease control rate. Dalantercept has a favorable safety profile, with fluid retention and edema being the most common side effects. Current studies are investigating the role of dalantercept with cytotoxic chemotherapy and other targeted therapies.

Duke Scholars

Published In

Drugs of the Future

DOI

ISSN

0377-8282

Publication Date

October 1, 2015

Volume

40

Issue

10

Start / End Page

633 / 637

Related Subject Headings

  • Medicinal & Biomolecular Chemistry
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hector-Greene, M. E., & Blobe, G. C. (2015). Dalantercept. Drugs of the Future, 40(10), 633–637. https://doi.org/10.1358/dof.2015.040.10.2386993
Hector-Greene, M. E., and G. C. Blobe. “Dalantercept.” Drugs of the Future 40, no. 10 (October 1, 2015): 633–37. https://doi.org/10.1358/dof.2015.040.10.2386993.
Hector-Greene ME, Blobe GC. Dalantercept. Drugs of the Future. 2015 Oct 1;40(10):633–7.
Hector-Greene, M. E., and G. C. Blobe. “Dalantercept.” Drugs of the Future, vol. 40, no. 10, Oct. 2015, pp. 633–37. Scopus, doi:10.1358/dof.2015.040.10.2386993.
Hector-Greene ME, Blobe GC. Dalantercept. Drugs of the Future. 2015 Oct 1;40(10):633–637.

Published In

Drugs of the Future

DOI

ISSN

0377-8282

Publication Date

October 1, 2015

Volume

40

Issue

10

Start / End Page

633 / 637

Related Subject Headings

  • Medicinal & Biomolecular Chemistry
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences