Defining the Role of Dexmedetomidine in the Prevention of Delirium in the Intensive Care Unit.

Published

Journal Article (Review)

Dexmedetomidine is a highly selective α 2 agonist used as a sedative agent. It also provides anxiolysis and sympatholysis without significant respiratory compromise or delirium. We conducted a systematic review to examine whether sedation of patients in the intensive care unit (ICU) with dexmedetomidine was associated with a lower incidence of delirium as compared to other nondexmedetomidine sedation strategies. A search of PUBMED, EMBASE, and the Cochrane Database of Systematic Reviews yielded only three trials from 1966 through April 2015 that met our predefined inclusion criteria and assessed dexmedetomidine and outcomes of delirium as their primary endpoint. The studies varied in regard to population, comparator sedation regimen, delirium outcome measure, and dexmedetomidine dosing. All trials are limited by design issues that limit our ability definitively to conclude that dexmedetomidine prevents delirium. Evidence does suggest that dexmedetomidine may allow for avoidance of deep sedation and use of benzodiazepines, factors both observed to increase the risk for developing delirium. Our assessment of currently published literature highlights the need for ongoing research to better delineate the role of dexmedetomidine for delirium prevention.

Full Text

Duke Authors

Cited Authors

  • Nelson, S; Muzyk, AJ; Bucklin, MH; Brudney, S; Gagliardi, JP

Published Date

  • 2015

Published In

Volume / Issue

  • 2015 /

Start / End Page

  • 635737 -

PubMed ID

  • 26576429

Pubmed Central ID

  • 26576429

Electronic International Standard Serial Number (EISSN)

  • 2314-6141

Digital Object Identifier (DOI)

  • 10.1155/2015/635737

Language

  • eng

Conference Location

  • United States