Size of sentinel node tumor deposits and extent of axillary lymph node involvement: which breast cancer patients may benefit from less aggressive axillary dissections?

Published

Journal Article

BACKGROUND: In most breast cancer series, nearly 30% to 40% of all patients are sentinel node positive; however, in a large proportion of these, the disease is limited to three or fewer positive nodes. On the basis of these observations, the object of this study is to identify a subset of patients who might benefit from a less aggressive axillary dissection, without compromising staging or local disease control. We reviewed known clinicopathologic variables associated with a higher risk for axillary metastasis in 467 patients who underwent sentinel node mapping at our institution. We then compared the incidence of these variables in patients with N1a versus N2-3 stage disease. RESULTS: Although the presence of lymphvascular invasion in the primary tumor and extracapsular extension of tumor in the sentinel node were statistically significantly different between N1a and N2-3 patients (P < .025 and P < .01, respectively), the variable that most reliably separated N1a from N2-3 patients was the size of the tumor deposits in the sentinel node (P < .001). All patients with sentinel node tumor deposits

Full Text

Duke Authors

Cited Authors

  • Samoilova, E; Davis, JT; Hinson, J; Brill, YM; Cibull, ML; McGrath, P; Romond, E; Moore, A; Samayoa, LM

Published Date

  • August 2007

Published In

Volume / Issue

  • 14 / 8

Start / End Page

  • 2221 - 2227

PubMed ID

  • 17549569

Pubmed Central ID

  • 17549569

International Standard Serial Number (ISSN)

  • 1068-9265

Digital Object Identifier (DOI)

  • 10.1245/s10434-007-9458-9

Language

  • eng

Conference Location

  • United States