The macrophage: Switches from a passenger to a driver during anticancer therapy


Journal Article

© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. We have recently discovered that BRAF inhibitors induce potent macrophage responses that confer melanoma resistance to therapy. Our studies lay a foundation for the hypothesis that macrophages switch their role from a passenger to a driver for tumor survival during therapeutic treatment, suggesting that agents that target macrophages can be an important component of “cocktail” anticancer therapy.

Full Text

Duke Authors

Cited Authors

  • Wang, T; Feldman, GM; Herlyn, M; Kaufman, RE

Published Date

  • January 1, 2015

Published In

Volume / Issue

  • 4 / 12

Electronic International Standard Serial Number (EISSN)

  • 2162-402X

International Standard Serial Number (ISSN)

  • 2162-4011

Digital Object Identifier (DOI)

  • 10.1080/2162402X.2015.1052929

Citation Source

  • Scopus