The macrophage: Switches from a passenger to a driver during anticancer therapy.

Journal Article (Journal Article)

We have recently discovered that BRAF inhibitors induce potent macrophage responses that confer melanoma resistance to therapy. Our studies lay a foundation for the hypothesis that macrophages switch their role from a passenger to a driver for tumor survival during therapeutic treatment, suggesting that agents that target macrophages can be an important component of "cocktail" anticancer therapy.

Full Text

Duke Authors

Cited Authors

  • Wang, T; Feldman, GM; Herlyn, M; Kaufman, RE

Published Date

  • December 2015

Published In

Volume / Issue

  • 4 / 12

Start / End Page

  • e1052929 -

PubMed ID

  • 26587324

Pubmed Central ID

  • PMC4635944

International Standard Serial Number (ISSN)

  • 2162-4011

Digital Object Identifier (DOI)

  • 10.1080/2162402X.2015.1052929


  • eng

Conference Location

  • United States