Banff 2013 meeting report: inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions.

Conference Paper

The 12th Banff Conference on Allograft Pathology was held in Comandatuba, Brazil, from August 19-23, 2013, and was preceded by a 2-day Latin American Symposium on Transplant Immunobiology and Immunopathology. The meeting was highlighted by the presentation of the findings of several working groups formed at the 2009 and 2011 Banff meetings to: (1) establish consensus criteria for diagnosing antibody-mediated rejection (ABMR) in the presence and absence of detectable C4d deposition; (2) develop consensus definitions and thresholds for glomerulitis (g score) and chronic glomerulopathy (cg score), associated with improved inter-observer agreement and correlation with clinical, molecular and serological data; (3) determine whether isolated lesions of intimal arteritis ("isolated v") represent acute rejection similar to intimal arteritis in the presence of tubulointerstitial inflammation; (4) compare different methodologies for evaluating interstitial fibrosis and for performing/evaluating implantation biopsies of renal allografts with regard to reproducibility and prediction of subsequent graft function; and (5) define clinically and prognostically significant morphologic criteria for subclassifying polyoma virus nephropathy. The key outcome of the 2013 conference is defining criteria for diagnosis of C4d-negative ABMR and respective modification of the Banff classification. In addition, three new Banff Working Groups were initiated.

Full Text

Duke Authors

Cited Authors

  • Haas, M; Sis, B; Racusen, LC; Solez, K; Glotz, D; Colvin, RB; Castro, MCR; David, DSR; David-Neto, E; Bagnasco, SM; Cendales, LC; Cornell, LD; Demetris, AJ; Drachenberg, CB; Farver, CF; Farris, AB; Gibson, IW; Kraus, E; Liapis, H; Loupy, A; Nickeleit, V; Randhawa, P; Rodriguez, ER; Rush, D; Smith, RN; Tan, CD; Wallace, WD; Mengel, M; Banff meeting report writing committee,

Published Date

  • February 2014

Published In

Volume / Issue

  • 14 / 2

Start / End Page

  • 272 - 283

PubMed ID

  • 24472190

Electronic International Standard Serial Number (EISSN)

  • 1600-6143

Digital Object Identifier (DOI)

  • 10.1111/ajt.12590

Conference Location

  • United States