Immunologic considerations in composite tissue transplantation: overview.
Published
Journal Article (Review)
Successful clinical transplantation of the upper extremity has been performed in several centers. In contrast with the recipients of other immediately vascularized organ allografts, the candidate for upper extremity transplantation has been, at least during the initial effort, a healthy patient. Although it is clear that composite tissue transplantation (CTA) is a form of allografting that behaves in many ways similarly to immediately vascularized organ allografts, the issue of developing immunologic understanding of such new allografts, awaits greater clinical experience. A summary of the immunosuppressive management of the patients who received hand allografts, with a view to explore the immunologic advantages and disadvantages as well as graft toxicity of the commonly used agents, is reported. This brief overview of the immunologic considerations in CTA is presented with the purpose of summarizing the main issues that contribute to the ultimate goal of achieving tolerance. These considerations include (1) the recipients before transplantation, (2) the donors including possible pretreatment, (3) immunosuppression for induction, maintenance, and treatment of acute rejection and its diagnosis, and (4) future potential for tolerance induction.
Full Text
Duke Authors
Cited Authors
- Cendales, L; Hardy, MA
Published Date
- 2000
Published In
Volume / Issue
- 20 / 8
Start / End Page
- 412 - 419
PubMed ID
- 11150993
Pubmed Central ID
- 11150993
International Standard Serial Number (ISSN)
- 0738-1085
Digital Object Identifier (DOI)
- 10.1002/1098-2752(2000)20:8<412::aid-micr12>3.0.co;2-m
Language
- eng
Conference Location
- United States