Factors associated with survival in pediatric adrenocortical carcinoma: An analysis of the National Cancer Data Base (NCDB).
Journal Article (Journal Article)
PURPOSE: Adrenocortical carcinoma (ACC) is a rare tumor in children with important distinctions from the adult disease. We reviewed the National Cancer Data Base (NCDB) to determine factors associated with long-term survival. METHODS: The NCDB was queried for patients less than 18 years of age who were diagnosed with ACC between 1998 and 2011. Kaplan-Meier analysis was utilized to determine factors significantly associated with overall survival. RESULTS: A total of 111 patients were included (median age: 4 years, 69% female). ACC was more common in the youngest cohort, with 48% of cases occurring in children younger than the age of 3. Median tumor size was 9.5 cm (IQR: 6.5-13.0), and 87% of patients underwent some form of surgical resection. Among children with available data, 19 of 62 presented with metastases. Overall 1- and 3-year survival was 70% and 64%, respectively. Age, tumor size, extension of tumor into surrounding tissue, and metastatic disease were all found to be significantly associated with survival. Among patients who underwent a surgical procedure, margin status was also found to be significantly associated with survival. CONCLUSION: Age, tumor size, extension of tumor, metastatic disease, and margin status are significantly associated with long-term survival in children with adrenocortical carcinoma.
Full Text
Duke Authors
Cited Authors
- Gulack, BC; Rialon, KL; Englum, BR; Kim, J; Talbot, LJ; Adibe, OO; Rice, HE; Tracy, ET
Published Date
- January 2016
Published In
Volume / Issue
- 51 / 1
Start / End Page
- 172 - 177
PubMed ID
- 26572849
Pubmed Central ID
- 26572849
Electronic International Standard Serial Number (EISSN)
- 1531-5037
Digital Object Identifier (DOI)
- 10.1016/j.jpedsurg.2015.10.039
Language
- eng
Conference Location
- United States