A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies.

Published

Journal Article

Previous studies have shown that sera from HIV-1-infected individuals contain antibodies able to mediate antibody-dependent cellular cytotoxicity (ADCC). These antibodies preferentially recognize envelope glycoprotein (Env) epitopes induced upon CD4 binding. Here, we show that a highly conserved tryptophan at position 69 of the gp120 inner domain is important for ADCC mediated by anti-cluster A antibodies and sera from HIV-1-infected individuals.

Full Text

Duke Authors

Cited Authors

  • Ding, S; Veillette, M; Coutu, M; Prévost, J; Scharf, L; Bjorkman, PJ; Ferrari, G; Robinson, JE; Stürzel, C; Hahn, BH; Sauter, D; Kirchhoff, F; Lewis, GK; Pazgier, M; Finzi, A

Published Date

  • February 2016

Published In

Volume / Issue

  • 90 / 4

Start / End Page

  • 2127 - 2134

PubMed ID

  • 26637462

Pubmed Central ID

  • 26637462

Electronic International Standard Serial Number (EISSN)

  • 1098-5514

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/JVI.02779-15

Language

  • eng