The Biology of Pulmonary Metastasis.

Journal Article (Journal Article;Review)

The process of metastasis relies on a series of stochastic and sequential steps, with selective pressure exerted on a large number of genetically volatile cancer cells to produce a very small fraction of tumor cells with the ability to navigate the transition from primary tumor cell to end-organ metastasis. This process is intricately determined by cell-microenvironment interactions, the mechanistic understanding of which is steadily increasing. The continued elucidation of pathways that govern these interactions offers potential therapeutic options to patients with advanced disease.

Full Text

Duke Authors

Cited Authors

  • Scott, CD; Harpole, DH

Published Date

  • February 2016

Published In

Volume / Issue

  • 26 / 1

Start / End Page

  • 1 - 6

PubMed ID

  • 26611504

Electronic International Standard Serial Number (EISSN)

  • 1558-5069

Digital Object Identifier (DOI)

  • 10.1016/j.thorsurg.2015.09.001


  • eng

Conference Location

  • United States