Gold-Catalyzed Intermolecular anti-Markovnikov Hydroamination of Methylenecyclopropanes with 2-Pyridones
Journal Article (Review;Journal)
The cationic gold phosphine complex [(o-biphenylPCy )Au(NCMe)] SbF catalyzes the intermolecular, anti-Markovnikov hydroamination of methylenecyclopropanes (MCPs) with 2-pyridones at 80 C. The transformation was effective for a range of pyridones and for monosubstituted and cis- and trans-disubstituted MCPs to form 1-cyclopropylmethyl-2-pyridones with excellent regio- and diastereoselectivity in moderate to good yields. 2 6 + -
Full Text
Duke Authors
Cited Authors
- Timmerman, JC; Widenhoefer, RA
Published Date
- November 16, 2015
Published In
Volume / Issue
- 357 / 16-17
Start / End Page
- 3703 - 3706
Electronic International Standard Serial Number (EISSN)
- 1615-4169
International Standard Serial Number (ISSN)
- 1615-4150
Digital Object Identifier (DOI)
- 10.1002/adsc.201500866
Citation Source
- Scopus