Gold-Catalyzed Intermolecular anti-Markovnikov Hydroamination of Methylenecyclopropanes with 2-Pyridones


Journal Article (Review)

© 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. The cationic gold phosphine complex [(o-biphenylPCy2)Au(NCMe)]+ SbF6- catalyzes the intermolecular, anti-Markovnikov hydroamination of methylenecyclopropanes (MCPs) with 2-pyridones at 80 C. The transformation was effective for a range of pyridones and for monosubstituted and cis- and trans-disubstituted MCPs to form 1-cyclopropylmethyl-2-pyridones with excellent regio- and diastereoselectivity in moderate to good yields.

Full Text

Duke Authors

Cited Authors

  • Timmerman, JC; Widenhoefer, RA

Published Date

  • November 16, 2015

Published In

Volume / Issue

  • 357 / 16-17

Start / End Page

  • 3703 - 3706

Electronic International Standard Serial Number (EISSN)

  • 1615-4169

International Standard Serial Number (ISSN)

  • 1615-4150

Digital Object Identifier (DOI)

  • 10.1002/adsc.201500866

Citation Source

  • Scopus