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Metastatic patterns in adenocarcinoma.

Publication ,  Journal Article
Hess, KR; Varadhachary, GR; Taylor, SH; Wei, W; Raber, MN; Lenzi, R; Abbruzzese, JL
Published in: Cancer
April 1, 2006

BACKGROUND: Unique metastatic patterns cited in the literature often arise from anecdotal clinical observations and autopsy reports. The authors analyzed clinical data from a large number of patients with histologically confirmed, distant-stage adenocarcinoma to evaluate metastatic patterns. METHODS: Tumor registry data were collected between 1994-1996 on 11 primary tumor sites and 15 metastatic sites from 4399 patients. The primary and metastatic sites were cross-tabulated in various ways to identify patterns, and the authors developed algorithms by using multinomial logistic regression analysis to predict the locations of primary tumors based on metastatic patterns. RESULTS: Three primary tumors had single, dominant metastatic sites: ovary to abdominal cavity (91%), prostate to bone (90%), and pancreas to liver (85%). The liver was the dominant metastatic site for gastrointestinal (GI) primary tumors (71% of patients), whereas bone and lung metastases were noted most frequently in non-GI primary tumors (43% and 29%, respectively). In a study of combinations of liver, abdominal cavity, and bone metastases, 86% of prostate primary tumors had only bone metastases, 80% of ovarian primary tumors had only abdominal cavity metastases, and 74% of pancreas primary tumors had only liver metastases. A single organ was the dominant source of metastases in 7 sites: axillary lymph node from the breast (97%), intestinal lymph node from the colon (84%), thoracic lymph node from the lung (66%), brain from the lung (64%), mediastinal lymph node from the lung (62%), supraclavicular lymph node from the breast (51%), and adrenal gland from the lung (51%). CONCLUSIONS: The algorithms that the authors developed achieved a cross-validated accuracy of 64% and an accuracy of 64% on an 1851-patient independent test set, compared with 9% accuracy when a random classifier was used.

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Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

April 1, 2006

Volume

106

Issue

7

Start / End Page

1624 / 1633

Location

United States

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Registries
  • Oncology & Carcinogenesis
  • Neoplasm Metastasis
  • Middle Aged
  • Male
  • Lymphatic Metastasis
  • Humans
  • Female
 

Citation

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Chicago
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Hess, K. R., Varadhachary, G. R., Taylor, S. H., Wei, W., Raber, M. N., Lenzi, R., & Abbruzzese, J. L. (2006). Metastatic patterns in adenocarcinoma. Cancer, 106(7), 1624–1633. https://doi.org/10.1002/cncr.21778
Hess, Kenneth R., Gauri R. Varadhachary, Sarah H. Taylor, Wei Wei, Martin N. Raber, Renato Lenzi, and James L. Abbruzzese. “Metastatic patterns in adenocarcinoma.Cancer 106, no. 7 (April 1, 2006): 1624–33. https://doi.org/10.1002/cncr.21778.
Hess KR, Varadhachary GR, Taylor SH, Wei W, Raber MN, Lenzi R, et al. Metastatic patterns in adenocarcinoma. Cancer. 2006 Apr 1;106(7):1624–33.
Hess, Kenneth R., et al. “Metastatic patterns in adenocarcinoma.Cancer, vol. 106, no. 7, Apr. 2006, pp. 1624–33. Pubmed, doi:10.1002/cncr.21778.
Hess KR, Varadhachary GR, Taylor SH, Wei W, Raber MN, Lenzi R, Abbruzzese JL. Metastatic patterns in adenocarcinoma. Cancer. 2006 Apr 1;106(7):1624–1633.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

April 1, 2006

Volume

106

Issue

7

Start / End Page

1624 / 1633

Location

United States

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Registries
  • Oncology & Carcinogenesis
  • Neoplasm Metastasis
  • Middle Aged
  • Male
  • Lymphatic Metastasis
  • Humans
  • Female