Phase II trial of 9-aminocamptothecin (NSC 603071) administered as a 120-hr continuous infusion weekly for three weeks in metastatic colorectal carcinoma.

Published

Journal Article

9-Aminocamptothecin (9-AC) is a camptothecin derivative with broad antitumor activity in preclinical studies. Prior investigations suggested that prolonged maintenance of 9-AC lactone plasma concentrations above 10 nmol/l and frequent administration of the drug are important determinants of antitumor activity. Our phase II study, therefore, examined a 5-day continuous infusion of 9-AC weekly for 3 weeks in patients with advanced colorectal cancer. Eighteen patients previously untreated for metastatic disease received 480 microg/m2/day of 9-AC. No responses were observed in 17 evaluable patients. Severe toxicities included granulocytopenia, nausea, vomiting and diarrhea. The median absolute granulocyte count (AGC) nadir was 2,300/microl (range 0-9,000/microl) and occurred on day 10. Eight patients received an escalated dose of 600 microg/m2/day. The median AGC nadir at the escalated dose was 1,500/microl (range: 300-2,700/microl) and occurred on day 22. The median number of courses given was 2 (range: 1-8); and the median time to disease progression was 8 weeks (range: 1-40 weeks). 9-AC administered by this schedule lacked antitumor activity in patients with advanced colorectal carcinomas.

Full Text

Duke Authors

Cited Authors

  • Pazdur, R; Medgyesy, DC; Winn, RJ; Dakhil, SR; Moore, DF; Scalzo, A; Hoff, PM; Arbuck, SG; Abbruzzese, JL

Published Date

  • January 1, 1998

Published In

Volume / Issue

  • 16 / 4

Start / End Page

  • 341 - 346

PubMed ID

  • 10426669

Pubmed Central ID

  • 10426669

International Standard Serial Number (ISSN)

  • 0167-6997

Language

  • eng

Conference Location

  • United States