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A pilot study of paclitaxel in previously treated patients with metastatic unknown primary carcinomas

Publication ,  Journal Article
Lenzi, R; Raber, MN; Schmidt, SB; Abbruzzese, JL
Published in: Oncology Reports
January 1, 1995

We enrolled 12 patients in a pilot phase II study to evaluate the efficacy and toxicity of paclitaxel as a single agent in the salvage treatment of patients with metastatic unknown primary carcinoma (UPC). Patients were given 175 mg/m2 of paclitaxel as a three-hour infusion. One patient was enrolled into the study with a diagnosis of poorly differentiated carcinoma but was found after another biopsy to have a soft tissue sarcoma and was therefore not included in this study. All patients had progressive disease after receiving at least one prior chemotherapy regimen containing cisplatin. Two patients had also received radiation therapy. Seven patients had adenocarcinomas, two patients had poorly differentiated adenocarcinomas and two had poorly differentiated carcinomas (PDC). Four patients experienced grade IV granulocytopenia and two patients experienced grade II nausea and vomiting. No responses were observed, and the study was terminated without enrolling more patients. At the dose level used in this study, paclitaxel was inactive in the treatment of patients with UPC whose cancer was resistant to cisplatin.

Duke Scholars

Published In

Oncology Reports

DOI

ISSN

1021-335X

Publication Date

January 1, 1995

Volume

2

Issue

6

Start / End Page

1127 / 1128

Related Subject Headings

  • 1112 Oncology and Carcinogenesis
 

Citation

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MLA
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Lenzi, R., Raber, M. N., Schmidt, S. B., & Abbruzzese, J. L. (1995). A pilot study of paclitaxel in previously treated patients with metastatic unknown primary carcinomas. Oncology Reports, 2(6), 1127–1128. https://doi.org/10.3892/or.2.6.1127
Lenzi, R., M. N. Raber, S. B. Schmidt, and J. L. Abbruzzese. “A pilot study of paclitaxel in previously treated patients with metastatic unknown primary carcinomas.” Oncology Reports 2, no. 6 (January 1, 1995): 1127–28. https://doi.org/10.3892/or.2.6.1127.
Lenzi R, Raber MN, Schmidt SB, Abbruzzese JL. A pilot study of paclitaxel in previously treated patients with metastatic unknown primary carcinomas. Oncology Reports. 1995 Jan 1;2(6):1127–8.
Lenzi, R., et al. “A pilot study of paclitaxel in previously treated patients with metastatic unknown primary carcinomas.” Oncology Reports, vol. 2, no. 6, Jan. 1995, pp. 1127–28. Scopus, doi:10.3892/or.2.6.1127.
Lenzi R, Raber MN, Schmidt SB, Abbruzzese JL. A pilot study of paclitaxel in previously treated patients with metastatic unknown primary carcinomas. Oncology Reports. 1995 Jan 1;2(6):1127–1128.

Published In

Oncology Reports

DOI

ISSN

1021-335X

Publication Date

January 1, 1995

Volume

2

Issue

6

Start / End Page

1127 / 1128

Related Subject Headings

  • 1112 Oncology and Carcinogenesis