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NF-κB activity blockade impairs the angiogenic potential of human pancreatic cancer cells

Publication ,  Journal Article
Xiong, HQ; Abbruzzese, JL; Lin, E; Wang, L; Zheng, L; Xie, K
Published in: International Journal of Cancer
January 10, 2004

The effect of blockade of NF-κB activity on human pancreatic cancer angiogenesis was determined in an orthotopic xenograft model. Highly metastatic L3.3 human pancreatic cancer cells, which expressed an elevated level of constitutive NF-κB activity, were transfected with a mutated IκBα (IκBαM). After implantation in the pancreas of nude mice, parental (L3.3) and control vector-transfected (L3.3-Neo) cells produced rapidly growing tumors and liver metastases, whereas IκBαM-transfected (L3.3-IκBαM) cells had decreased tumorigenicity and metastatic potential. NF-κB signaling blockade significantly inhibited the in vitro and in vivo expression of the major proangiogenic molecules vascular endothelial growth factor and interleukin-8 and decreased tumor vascular formation. These events were correlated with retarded tumor growth and suppression of metastasis. Collectively, these data suggest that suppression of tumorigenicity and metastasis by NF-κB blockade is due to impaired angiogenic potential of tumor cells. © 2003 Wiley-Liss, Inc.

Duke Scholars

Published In

International Journal of Cancer

DOI

ISSN

0020-7136

Publication Date

January 10, 2004

Volume

108

Issue

2

Start / End Page

181 / 188

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

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Xiong, H. Q., Abbruzzese, J. L., Lin, E., Wang, L., Zheng, L., & Xie, K. (2004). NF-κB activity blockade impairs the angiogenic potential of human pancreatic cancer cells. International Journal of Cancer, 108(2), 181–188. https://doi.org/10.1002/ijc.11562
Xiong, H. Q., J. L. Abbruzzese, E. Lin, L. Wang, L. Zheng, and K. Xie. “NF-κB activity blockade impairs the angiogenic potential of human pancreatic cancer cells.” International Journal of Cancer 108, no. 2 (January 10, 2004): 181–88. https://doi.org/10.1002/ijc.11562.
Xiong HQ, Abbruzzese JL, Lin E, Wang L, Zheng L, Xie K. NF-κB activity blockade impairs the angiogenic potential of human pancreatic cancer cells. International Journal of Cancer. 2004 Jan 10;108(2):181–8.
Xiong, H. Q., et al. “NF-κB activity blockade impairs the angiogenic potential of human pancreatic cancer cells.” International Journal of Cancer, vol. 108, no. 2, Jan. 2004, pp. 181–88. Scopus, doi:10.1002/ijc.11562.
Xiong HQ, Abbruzzese JL, Lin E, Wang L, Zheng L, Xie K. NF-κB activity blockade impairs the angiogenic potential of human pancreatic cancer cells. International Journal of Cancer. 2004 Jan 10;108(2):181–188.
Journal cover image

Published In

International Journal of Cancer

DOI

ISSN

0020-7136

Publication Date

January 10, 2004

Volume

108

Issue

2

Start / End Page

181 / 188

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis