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Patterns of self-reported symptoms in pancreatic cancer patients receiving chemoradiation.

Publication ,  Journal Article
Reyes-Gibby, CC; Chan, W; Abbruzzese, JL; Xiong, HQ; Ho, L; Evans, DB; Varadhachary, G; Bhat, S; Wolff, RA; Crane, C
Published in: J Pain Symptom Manage
September 2007

Pancreatic cancer is a lethal disease characterized by multiple disease-related symptoms. Chemoradiation therapy is a standard of treatment for locally advanced pancreatic cancer. Although shown to prolong survival, there is little information about treatment-related symptoms or the palliative benefits of chemoradiation. We assessed symptoms of patients with locally advanced pancreatic cancer receiving chemoradiation to determine the prevalence, and co-occurrence, of symptoms and to identify the extent to which symptoms interfered with function. Forty-eight patients were treated with chemoradiation on a Phase I protocol. Patients received radiotherapy (50.4 Gy in 28 fractions), capecitabine (median dose 825 mg/m(2) twice daily), and bevacizumab (2.5-10 mg/kg). Symptom severity and its interference with function were prospectively assessed (at presentation, during, and after chemoradiation) in 43 consenting patients using the M.D. Anderson Symptom Inventory. Results showed that 95% of patients reported at least one of the 13 symptoms assessed at presentation. The most commonly reported symptoms of moderate to severe (>or=5 on a 0-10 scale) intensity at presentation were lack of appetite (24%), pain (19%), fatigue (19%), and sleep disturbance (10%). We observed an increase in patients reporting moderate to severe fatigue, nausea, and sleep disturbance during chemoradiation. McNemar tests for paired binary observations showed the proportion of patients reporting moderate to severe symptoms significantly (P<0.001) decreased after chemoradiation at 94 days follow-up (lack of appetite=7%, pain=7%, fatigue=13%, sleep disturbance=7%). This study demonstrates the feasibility and usefulness of symptom assessment in chemoradiation protocols. Future studies with larger cohorts are needed to further characterize multiple symptoms associated with chemoradiation.

Duke Scholars

Published In

J Pain Symptom Manage

DOI

ISSN

0885-3924

Publication Date

September 2007

Volume

34

Issue

3

Start / End Page

244 / 252

Location

United States

Related Subject Headings

  • Sleep Wake Disorders
  • Prevalence
  • Pancreatic Neoplasms
  • Pain
  • Nausea
  • Middle Aged
  • Male
  • Humans
  • Female
  • Fatigue
 

Citation

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Reyes-Gibby, C. C., Chan, W., Abbruzzese, J. L., Xiong, H. Q., Ho, L., Evans, D. B., … Crane, C. (2007). Patterns of self-reported symptoms in pancreatic cancer patients receiving chemoradiation. J Pain Symptom Manage, 34(3), 244–252. https://doi.org/10.1016/j.jpainsymman.2006.11.007
Reyes-Gibby, Cielito C., Wenyaw Chan, James L. Abbruzzese, Henry Q. Xiong, Linus Ho, Douglas B. Evans, Gauri Varadhachary, Samrat Bhat, Robert A. Wolff, and Christopher Crane. “Patterns of self-reported symptoms in pancreatic cancer patients receiving chemoradiation.J Pain Symptom Manage 34, no. 3 (September 2007): 244–52. https://doi.org/10.1016/j.jpainsymman.2006.11.007.
Reyes-Gibby CC, Chan W, Abbruzzese JL, Xiong HQ, Ho L, Evans DB, et al. Patterns of self-reported symptoms in pancreatic cancer patients receiving chemoradiation. J Pain Symptom Manage. 2007 Sep;34(3):244–52.
Reyes-Gibby, Cielito C., et al. “Patterns of self-reported symptoms in pancreatic cancer patients receiving chemoradiation.J Pain Symptom Manage, vol. 34, no. 3, Sept. 2007, pp. 244–52. Pubmed, doi:10.1016/j.jpainsymman.2006.11.007.
Reyes-Gibby CC, Chan W, Abbruzzese JL, Xiong HQ, Ho L, Evans DB, Varadhachary G, Bhat S, Wolff RA, Crane C. Patterns of self-reported symptoms in pancreatic cancer patients receiving chemoradiation. J Pain Symptom Manage. 2007 Sep;34(3):244–252.
Journal cover image

Published In

J Pain Symptom Manage

DOI

ISSN

0885-3924

Publication Date

September 2007

Volume

34

Issue

3

Start / End Page

244 / 252

Location

United States

Related Subject Headings

  • Sleep Wake Disorders
  • Prevalence
  • Pancreatic Neoplasms
  • Pain
  • Nausea
  • Middle Aged
  • Male
  • Humans
  • Female
  • Fatigue