Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers.

Journal Article (Journal Article;Review)

The hedgehog (Hh) signaling pathway plays many roles in invertebrate and vertebrate development. For example, specific inhibition of sonic Hh expression is critical during early stages of pancreas organogenesis, but an active Hh pathway appears to be required for maintenance of adult endocrine functions. Mutational inactivation of the Hh pathway has been demonstrated in human malignancies of the skin, cerebellum, and skeletal muscle. Now, two papers implicate aberrant Hh signaling in human upper gastrointestinal cancers including those developing from the esophagus, stomach, biliary tract, and pancreas.

Full Text

Duke Authors

Cited Authors

  • Xie, K; Abbruzzese, JL

Published Date

  • October 1, 2003

Published In

Volume / Issue

  • 4 / 4

Start / End Page

  • 245 - 247

PubMed ID

  • 14585350

International Standard Serial Number (ISSN)

  • 1535-6108

Digital Object Identifier (DOI)

  • 10.1016/s1535-6108(03)00246-0


  • eng

Conference Location

  • United States