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Altered decamer and nonamer from an HLA-A0201-restricted epitope of Survivin differentially stimulate T-cell responses in different individuals.

Publication ,  Journal Article
Bernatchez, C; Zhu, K; Li, Y; Andersson, H; Ionnides, C; Fernandez-Vina, M; Cano, P; Cooper, L; Abbruzzese, J; Hwu, P; Chang, DZ; Radvanyi, LG
Published in: Vaccine
April 5, 2011

Survivin is a universal tumor antigen that is being currently targeted in vaccine approaches against cancer. Our study here examined the immunogenicity of a novel variant of an HLA-A0201-binding decamer peptide from region 95 to 104 of Survivin (ELMLGEFLKL) with a T→M modification at position 3 in the peptide. We found that this new modified 10-mer peptide had enhanced HLA-A0201 binding and induced a stronger T-cell response over its wild type counterpart peptide (ELTLGEFLKL) in select HLA-A0201(+) normal donors. In addition, when compared to the previously characterized altered 96-104 peptide (LMLGEFLKL) from the same region of Survivin currently used in vaccine trials, we found that both peptides had similar immunogenicity, but donor T cells preferentially reacted strongly to either one or the other, but not strongly to both. These results suggest that these two closely related Survivin peptides yield distinct T-cell responses and that most individuals dominantly respond to one or the other altered peptide. We also found a novel association between positive reactivity to the new altered decamer Survivin peptide in some individuals and their expression of the HLA-C0701 allele along with HLA-A0201. Thus, vaccinating with both the 10-mer and 9-mer peptides would be required to immunize a maximum number of individuals in the HLA-A0201(+) population and could lead to more consistent T-cell responses against this region of Survivin.

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Published In

Vaccine

DOI

EISSN

1873-2518

Publication Date

April 5, 2011

Volume

29

Issue

16

Start / End Page

3021 / 3030

Location

Netherlands

Related Subject Headings

  • Virology
  • T-Lymphocytes
  • Survivin
  • Protein Binding
  • Peptides
  • Models, Molecular
  • Inhibitor of Apoptosis Proteins
  • Humans
  • HLA-A2 Antigen
  • HLA-A Antigens
 

Citation

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Bernatchez, C., Zhu, K., Li, Y., Andersson, H., Ionnides, C., Fernandez-Vina, M., … Radvanyi, L. G. (2011). Altered decamer and nonamer from an HLA-A0201-restricted epitope of Survivin differentially stimulate T-cell responses in different individuals. Vaccine, 29(16), 3021–3030. https://doi.org/10.1016/j.vaccine.2011.01.115
Bernatchez, Chantale, Kuichin Zhu, Yufeng Li, Helen Andersson, Constantin Ionnides, Marcelo Fernandez-Vina, Pedro Cano, et al. “Altered decamer and nonamer from an HLA-A0201-restricted epitope of Survivin differentially stimulate T-cell responses in different individuals.Vaccine 29, no. 16 (April 5, 2011): 3021–30. https://doi.org/10.1016/j.vaccine.2011.01.115.
Bernatchez C, Zhu K, Li Y, Andersson H, Ionnides C, Fernandez-Vina M, et al. Altered decamer and nonamer from an HLA-A0201-restricted epitope of Survivin differentially stimulate T-cell responses in different individuals. Vaccine. 2011 Apr 5;29(16):3021–30.
Bernatchez, Chantale, et al. “Altered decamer and nonamer from an HLA-A0201-restricted epitope of Survivin differentially stimulate T-cell responses in different individuals.Vaccine, vol. 29, no. 16, Apr. 2011, pp. 3021–30. Pubmed, doi:10.1016/j.vaccine.2011.01.115.
Bernatchez C, Zhu K, Li Y, Andersson H, Ionnides C, Fernandez-Vina M, Cano P, Cooper L, Abbruzzese J, Hwu P, Chang DZ, Radvanyi LG. Altered decamer and nonamer from an HLA-A0201-restricted epitope of Survivin differentially stimulate T-cell responses in different individuals. Vaccine. 2011 Apr 5;29(16):3021–3030.
Journal cover image

Published In

Vaccine

DOI

EISSN

1873-2518

Publication Date

April 5, 2011

Volume

29

Issue

16

Start / End Page

3021 / 3030

Location

Netherlands

Related Subject Headings

  • Virology
  • T-Lymphocytes
  • Survivin
  • Protein Binding
  • Peptides
  • Models, Molecular
  • Inhibitor of Apoptosis Proteins
  • Humans
  • HLA-A2 Antigen
  • HLA-A Antigens