The convergence of cancer prevention and therapy in early-phase clinical drug development.
Publication
, Journal Article
Abbruzzese, JL; Lippman, SM
Published in: Cancer Cell
October 2004
After decades of separate but not equal drug development, prevention and therapy are beginning to converge at the level of early-phase clinical testing. This highly beneficial convergence is due to spectacular molecular advances in our understanding of neoplasia (both cancer and precancer), cancer risk and prognosis, and the mechanisms by which novel drugs with less toxicity and more cytostatic activity profiles target specific molecular events to suppress malignant and premalignant cells. The future full convergence of prevention-therapy drug development (aided by technological advances, such as in molecular imaging) promises to hasten the progress of oncology in reducing the public health impact of the major cancers.
Duke Scholars
Published In
Cancer Cell
DOI
ISSN
1535-6108
Publication Date
October 2004
Volume
6
Issue
4
Start / End Page
321 / 326
Location
United States
Related Subject Headings
- Oncology & Carcinogenesis
- Neoplasms
- Humans
- Drug Design
- Clinical Trials as Topic
- Antineoplastic Agents
- 3211 Oncology and carcinogenesis
- 3101 Biochemistry and cell biology
- 1112 Oncology and Carcinogenesis
- 1109 Neurosciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Abbruzzese, J. L., & Lippman, S. M. (2004). The convergence of cancer prevention and therapy in early-phase clinical drug development. Cancer Cell, 6(4), 321–326. https://doi.org/10.1016/j.ccr.2004.09.021
Abbruzzese, James L., and Scott M. Lippman. “The convergence of cancer prevention and therapy in early-phase clinical drug development.” Cancer Cell 6, no. 4 (October 2004): 321–26. https://doi.org/10.1016/j.ccr.2004.09.021.
Abbruzzese JL, Lippman SM. The convergence of cancer prevention and therapy in early-phase clinical drug development. Cancer Cell. 2004 Oct;6(4):321–6.
Abbruzzese, James L., and Scott M. Lippman. “The convergence of cancer prevention and therapy in early-phase clinical drug development.” Cancer Cell, vol. 6, no. 4, Oct. 2004, pp. 321–26. Pubmed, doi:10.1016/j.ccr.2004.09.021.
Abbruzzese JL, Lippman SM. The convergence of cancer prevention and therapy in early-phase clinical drug development. Cancer Cell. 2004 Oct;6(4):321–326.
Published In
Cancer Cell
DOI
ISSN
1535-6108
Publication Date
October 2004
Volume
6
Issue
4
Start / End Page
321 / 326
Location
United States
Related Subject Headings
- Oncology & Carcinogenesis
- Neoplasms
- Humans
- Drug Design
- Clinical Trials as Topic
- Antineoplastic Agents
- 3211 Oncology and carcinogenesis
- 3101 Biochemistry and cell biology
- 1112 Oncology and Carcinogenesis
- 1109 Neurosciences