Experimental animal models of pancreatic carcinogenesis and metastasis.

Journal Article (Review)

Pancreatic cancer is a lethal disease characterized by early metastasis, local invasion, and resistance to conventional therapies. To understand its etiology and eventually make prevention of it possible and effective, appropriate carcinogenesis models will certainly help us understand the effects of environmental and genetic elements on pancreatic carcinogenesis. The development of new treatment strategies to control cancer metastasis is of immediate urgency. Fulfillment of this task relies on our knowledge of the cellular and molecular biology of pancreatic cancer metastasis and the availability of biologically and clinically relevant model systems. Many of the existing pancreatic cancer carcinogenesis and metastasis animal models are described in this review. The advantages and disadvantages of each model and their clinical implications are discussed, and special attention is focused on experimental therapeutic strategies targeting pancreatic cancer metastasis.

Full Text

Duke Authors

Cited Authors

  • Wei, D; Xiong, HQ; Abbruzzese, JL; Xie, K

Published Date

  • January 2003

Published In

Volume / Issue

  • 33 / 1

Start / End Page

  • 43 - 60

PubMed ID

  • 12909737

Electronic International Standard Serial Number (EISSN)

  • 1559-0739

International Standard Serial Number (ISSN)

  • 1537-3649

Digital Object Identifier (DOI)

  • 10.1385/ijgc:33:1:43

Language

  • eng