Iron metabolism: iron deficiency and iron overload.

Journal Article (Journal Article;Review)

Iron is an essential cofactor in a variety of cellular processes. Except for a few unusual bacterial species, iron is indispensable for living organisms. However, free iron is toxic because of its propensity to induce the formation of dangerous free radicals. Consequently, iron balance is tightly regulated. Disorders of iron homeostasis are among the most common afflictions of humans. This review discusses inherited iron deficiency and iron overload disorders and recent insights into their pathophysiology.

Full Text

Duke Authors

Cited Authors

  • Andrews, NC

Published Date

  • 2000

Published In

Volume / Issue

  • 1 /

Start / End Page

  • 75 - 98

PubMed ID

  • 11701625

International Standard Serial Number (ISSN)

  • 1527-8204

Digital Object Identifier (DOI)

  • 10.1146/annurev.genom.1.1.75


  • eng

Conference Location

  • United States