The surgical approach to short bowel syndrome-autologous reconstruction versus transplantation

Journal Article (Review;Journal)

Background: Short bowel syndrome (SBS) is a state of malabsorption resulting from massive small bowel resection leading to parenteral nutrition (PN) dependency. Considerable advances have been achieved in the medical and surgical management of SBS over the last few decades. Methods: This review discusses in detail the surgical approach to SBS. Results: Widespread use of PN enables long-term survival in patients with intestinal failure but at the cost of PN-associated life-threatening complications including catheter-associated blood stream infection, venous thrombosis, and liver disease. The goal of management of intestinal failure due to SBS is to enable enteral autonomy and wean PN by means of a multi-disciplinary approach. Availability of modified enteral feeding formulas have simplified nutrition supplementation in SBS patients. Similarly, advances in the medical field have made medications like growth hormone and glucagon-like peptide (GLP2) available to improve water and nutrient absorption as well as to enable achieving enteral autonomy. Autologous gastrointestinal reconstruction (AGIR) includes various techniques which manipulate the bowel surgically to facilitate the bowel adaptation process and restoration of enteral nutrition. Ultimately, intestinal transplantation can serve as the last option for the cure of intestinal failure when selectively applied. Conclusion: SBS continues to be a challenging medical problem. Best patient outcomes can be achieved through an individualized plan, using various AGIR techniques to complement each other, and intestinal transplantation as a last resort for cure. Maximum benefit and improved outcomes can be achieved by caring for SBS patients at highly specialized intestinal rehabilitation centers. © 2014 S. Karger GmbH, Freiburg.

Full Text

Duke Authors

Cited Authors

  • Rege, A

Published Date

  • January 1, 2014

Published In

Volume / Issue

  • 30 / 3

Start / End Page

  • 179 - 189

Electronic International Standard Serial Number (EISSN)

  • 1662-6672

International Standard Serial Number (ISSN)

  • 1662-6664

Digital Object Identifier (DOI)

  • 10.1159/000363589

Citation Source

  • Scopus