Andexanet alfa for the reversal of Factor Xa inhibitor related anticoagulation.

Other Article (Journal Article;Review)

Andexanet alfa is a specific reversal agent for Factor Xa inhibitors. The molecule is a recombinant protein analog of factor Xa that binds to Factor Xa inhibitors and antithrombin:LMWH complex but does not trigger prothrombotic activity. In ex vivo, animal, and volunteer human studies, andexanet alfa (AnXa) was able to dose-dependently reverse Factor Xa inhibition and restore thrombin generation for the duration of drug administration. Further trials are underway to examine its safety and efficacy in the population of patients experiencing FXa inhibitor-related bleeding.

Full Text

Duke Authors

Cited Authors

  • Ghadimi, K; Dombrowski, KE; Levy, JH; Welsby, IJ

Published Date

  • 2016

Published In

Volume / Issue

  • 9 / 2

Start / End Page

  • 115 - 122

PubMed ID

  • 26686866

Electronic International Standard Serial Number (EISSN)

  • 1747-4094

Digital Object Identifier (DOI)

  • 10.1586/17474086.2016.1135046


  • eng

Conference Location

  • England