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One-carbon metabolism and epigenetics: understanding the specificity.

Publication ,  Journal Article
Mentch, SJ; Locasale, JW
Published in: Annals of the New York Academy of Sciences
January 2016

One-carbon metabolism is a metabolic network that integrates nutrient status from the environment to yield multiple biological functions. The folate and methionine cycles generate S-adenosylmethionine (SAM), which is the universal methyl donor for methylation reactions, including histone and DNA methylation. Histone methylation is a crucial part of the epigenetic code and plays diverse roles in the establishment of chromatin states that mediate the regulation of gene expression. The activities of histone methyltransferases (HMTs) are dependent on intracellular levels of SAM, which fluctuate based on cellular nutrient availability, providing a link between cell metabolism and histone methylation. Here we discuss the biochemical properties of HMTs, their role in gene regulation, and the connection to cellular metabolism. Our emphasis is on understanding the specificity of this intriguing link.

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Published In

Annals of the New York Academy of Sciences

DOI

EISSN

1749-6632

ISSN

0077-8923

Publication Date

January 2016

Volume

1363

Start / End Page

91 / 98

Related Subject Headings

  • Substrate Specificity
  • S-Adenosylmethionine
  • Methylation
  • Methionine
  • Metabolic Networks and Pathways
  • Kinetics
  • Humans
  • Histones
  • Histone-Lysine N-Methyltransferase
  • Histone Methyltransferases
 

Citation

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Mentch, S. J., & Locasale, J. W. (2016). One-carbon metabolism and epigenetics: understanding the specificity. Annals of the New York Academy of Sciences, 1363, 91–98. https://doi.org/10.1111/nyas.12956
Mentch, Samantha J., and Jason W. Locasale. “One-carbon metabolism and epigenetics: understanding the specificity.Annals of the New York Academy of Sciences 1363 (January 2016): 91–98. https://doi.org/10.1111/nyas.12956.
Mentch SJ, Locasale JW. One-carbon metabolism and epigenetics: understanding the specificity. Annals of the New York Academy of Sciences. 2016 Jan;1363:91–8.
Mentch, Samantha J., and Jason W. Locasale. “One-carbon metabolism and epigenetics: understanding the specificity.Annals of the New York Academy of Sciences, vol. 1363, Jan. 2016, pp. 91–98. Epmc, doi:10.1111/nyas.12956.
Mentch SJ, Locasale JW. One-carbon metabolism and epigenetics: understanding the specificity. Annals of the New York Academy of Sciences. 2016 Jan;1363:91–98.
Journal cover image

Published In

Annals of the New York Academy of Sciences

DOI

EISSN

1749-6632

ISSN

0077-8923

Publication Date

January 2016

Volume

1363

Start / End Page

91 / 98

Related Subject Headings

  • Substrate Specificity
  • S-Adenosylmethionine
  • Methylation
  • Methionine
  • Metabolic Networks and Pathways
  • Kinetics
  • Humans
  • Histones
  • Histone-Lysine N-Methyltransferase
  • Histone Methyltransferases