One-carbon metabolism and epigenetics: understanding the specificity.

Journal Article (Journal Article;Review)

One-carbon metabolism is a metabolic network that integrates nutrient status from the environment to yield multiple biological functions. The folate and methionine cycles generate S-adenosylmethionine (SAM), which is the universal methyl donor for methylation reactions, including histone and DNA methylation. Histone methylation is a crucial part of the epigenetic code and plays diverse roles in the establishment of chromatin states that mediate the regulation of gene expression. The activities of histone methyltransferases (HMTs) are dependent on intracellular levels of SAM, which fluctuate based on cellular nutrient availability, providing a link between cell metabolism and histone methylation. Here we discuss the biochemical properties of HMTs, their role in gene regulation, and the connection to cellular metabolism. Our emphasis is on understanding the specificity of this intriguing link.

Full Text

Duke Authors

Cited Authors

  • Mentch, SJ; Locasale, JW

Published Date

  • January 2016

Published In

Volume / Issue

  • 1363 /

Start / End Page

  • 91 - 98

PubMed ID

  • 26647078

Pubmed Central ID

  • PMC4801744

Electronic International Standard Serial Number (EISSN)

  • 1749-6632

Digital Object Identifier (DOI)

  • 10.1111/nyas.12956


  • eng

Conference Location

  • United States