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Benefits of a novel percutaneous ventricular assist device for right heart failure: The prospective RECOVER RIGHT study of the Impella RP device.

Publication ,  Journal Article
Anderson, MB; Goldstein, J; Milano, C; Morris, LD; Kormos, RL; Bhama, J; Kapur, NK; Bansal, A; Garcia, J; Baker, JN; Silvestry, S; Holman, WL ...
Published in: J Heart Lung Transplant
December 2015

BACKGROUND: Right ventricular failure (RVF) increases morbidity and mortality. The RECOVER RIGHT study evaluated the safety and efficacy of a novel percutaneous right ventricular assist device, the Impella RP (Abiomed, Danvers, MA), in a prospective, multicenter trial. METHODS: Thirty patients with RVF refractory to medical treatment received the Impella RP device at 15 United States institutions. The study population included 2 cohorts: 18 patients with RVF after left ventricular assist device (LVAD) implantation (Cohort A) and 12 patients with RVF after cardiotomy or myocardial infarction (Cohort B). The primary end point was survival to 30 days or hospital discharge (whichever was longer). Major secondary end points included indices of safety and efficacy. RESULTS: The patients (77% male) were a mean age of 59 ± 15 years, 53% had diabetes, 88.5% had a history of congestive heart failure, and 37.5% had renal dysfunction. Patients were on an average of 3.2 inotropes/pressors. Device delivery was achieved in all but 1 patient. Hemodynamics improved immediately after initiation of Impella RP support, with an increase in cardiac index from 1.8 ± 0.2 to 3.3 ± 0.23 liters/min/m(2) (p < 0.001) and a decrease in central venous pressure from 19.2 ± 4 to 12.6 ± 1 mm Hg (p < 0.001). Patients were supported for an average of 3.0 ± 1.5 days (range, 0.5-7.8 days). The overall survival at 30 days was 73.3%. All patients discharged were alive at 180 days. CONCLUSIONS: In patients with life-threatening RVF, the novel percutaneous Impella RP device was safe, easy to deploy, and reliably resulted in immediate hemodynamic benefit. These data support its probable benefit in this gravely ill patient population.

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Published In

J Heart Lung Transplant

DOI

EISSN

1557-3117

Publication Date

December 2015

Volume

34

Issue

12

Start / End Page

1549 / 1560

Location

United States

Related Subject Headings

  • Surgery
  • Prosthesis Design
  • Prospective Studies
  • Middle Aged
  • Male
  • Humans
  • Heart-Assist Devices
  • Heart Failure
  • Female
  • 3202 Clinical sciences
 

Citation

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Anderson, M. B., Goldstein, J., Milano, C., Morris, L. D., Kormos, R. L., Bhama, J., … O’Neill, W. (2015). Benefits of a novel percutaneous ventricular assist device for right heart failure: The prospective RECOVER RIGHT study of the Impella RP device. J Heart Lung Transplant, 34(12), 1549–1560. https://doi.org/10.1016/j.healun.2015.08.018
Anderson, Mark B., James Goldstein, Carmelo Milano, Lynn D. Morris, Robert L. Kormos, Jay Bhama, Navin K. Kapur, et al. “Benefits of a novel percutaneous ventricular assist device for right heart failure: The prospective RECOVER RIGHT study of the Impella RP device.J Heart Lung Transplant 34, no. 12 (December 2015): 1549–60. https://doi.org/10.1016/j.healun.2015.08.018.
Anderson MB, Goldstein J, Milano C, Morris LD, Kormos RL, Bhama J, et al. Benefits of a novel percutaneous ventricular assist device for right heart failure: The prospective RECOVER RIGHT study of the Impella RP device. J Heart Lung Transplant. 2015 Dec;34(12):1549–60.
Anderson, Mark B., et al. “Benefits of a novel percutaneous ventricular assist device for right heart failure: The prospective RECOVER RIGHT study of the Impella RP device.J Heart Lung Transplant, vol. 34, no. 12, Dec. 2015, pp. 1549–60. Pubmed, doi:10.1016/j.healun.2015.08.018.
Anderson MB, Goldstein J, Milano C, Morris LD, Kormos RL, Bhama J, Kapur NK, Bansal A, Garcia J, Baker JN, Silvestry S, Holman WL, Douglas PS, O’Neill W. Benefits of a novel percutaneous ventricular assist device for right heart failure: The prospective RECOVER RIGHT study of the Impella RP device. J Heart Lung Transplant. 2015 Dec;34(12):1549–1560.
Journal cover image

Published In

J Heart Lung Transplant

DOI

EISSN

1557-3117

Publication Date

December 2015

Volume

34

Issue

12

Start / End Page

1549 / 1560

Location

United States

Related Subject Headings

  • Surgery
  • Prosthesis Design
  • Prospective Studies
  • Middle Aged
  • Male
  • Humans
  • Heart-Assist Devices
  • Heart Failure
  • Female
  • 3202 Clinical sciences