Peripheral T-cell lymphoma, NOS, and anaplastic large cell lymphoma.

Journal Article

Peripheral T-cell lymphomas (PTCL), with the exception of anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL), have a very poor prognosis. Although current first line chemotherapy continues to be a CHOP-like (cyclophosphamide, doxorubicin, vincristine, prednisone) regimen there is now data suggesting that the addition of etoposide in younger patients improves outcomes. Even for those patients who do have a response to therapy, the risk of relapse remains quite high. Although autologous transplant in first remission is often used, its role as consolidation therapy in first remission remains unclear and may preferentially benefit low-risk patients. In the relapsed setting, major advances have occurred with Food and Drug Administration (FDA) approval of 4 new agents (pralatrexate, romidepsin, belinostat, brentuximab vedotin) for relapsed/refractory PTCL since 2009. These 4 drugs represent the first agents ever approved specifically for this indication. Unfortunately, with the exception of ALCL for which brentuximab vedotin will likely substantially change our approach to treatment, there are still many patients for whom available drugs will not be effective, and it is for these patients that further advances are urgently needed.

Full Text

Duke Authors

Cited Authors

  • Beaven, AW; Diehl, LF

Published Date

  • January 2015

Published In

Volume / Issue

  • 2015 /

Start / End Page

  • 550 - 558

PubMed ID

  • 26637771

Electronic International Standard Serial Number (EISSN)

  • 1520-4383

International Standard Serial Number (ISSN)

  • 1520-4391

Digital Object Identifier (DOI)

  • 10.1182/asheducation-2015.1.550

Language

  • eng