Impulse oscillometry identifies peripheral airway dysfunction in children with adenosine deaminase deficiency.
Journal Article (Letter)
Adenosine deaminase-deficient severe combined immunodeficiency (ADA-SCID) is characterized by impaired T-, B- and NK-cell function. Affected children, in addition to early onset of infections, manifest non-immunologic symptoms including pulmonary dysfunction likely attributable to elevated systemic adenosine levels. Lung disease assessment has primarily employed repetitive radiography and effort-dependent functional studies. Through impulse oscillometry (IOS), which is effort-independent, we prospectively obtained objective measures of lung dysfunction in 10 children with ADA-SCID. These results support the use of IOS in the identification and monitoring of lung function abnormalities in children with primary immunodeficiencies.
Full Text
Duke Authors
Cited Authors
- Komarow, HD; Sokolic, R; Hershfield, MS; Kohn, DB; Young, M; Metcalfe, DD; Candotti, F
Published Date
- December 18, 2015
Published In
Volume / Issue
- 10 /
Start / End Page
- 159 -
PubMed ID
- 26682746
Pubmed Central ID
- PMC4683718
Electronic International Standard Serial Number (EISSN)
- 1750-1172
Digital Object Identifier (DOI)
- 10.1186/s13023-015-0365-z
Language
- eng
Conference Location
- England