Impulse oscillometry identifies peripheral airway dysfunction in children with adenosine deaminase deficiency.

Published online

Journal Article (Letter)

Adenosine deaminase-deficient severe combined immunodeficiency (ADA-SCID) is characterized by impaired T-, B- and NK-cell function. Affected children, in addition to early onset of infections, manifest non-immunologic symptoms including pulmonary dysfunction likely attributable to elevated systemic adenosine levels. Lung disease assessment has primarily employed repetitive radiography and effort-dependent functional studies. Through impulse oscillometry (IOS), which is effort-independent, we prospectively obtained objective measures of lung dysfunction in 10 children with ADA-SCID. These results support the use of IOS in the identification and monitoring of lung function abnormalities in children with primary immunodeficiencies.

Full Text

Duke Authors

Cited Authors

  • Komarow, HD; Sokolic, R; Hershfield, MS; Kohn, DB; Young, M; Metcalfe, DD; Candotti, F

Published Date

  • December 18, 2015

Published In

Volume / Issue

  • 10 /

Start / End Page

  • 159 -

PubMed ID

  • 26682746

Pubmed Central ID

  • 26682746

Electronic International Standard Serial Number (EISSN)

  • 1750-1172

Digital Object Identifier (DOI)

  • 10.1186/s13023-015-0365-z

Language

  • eng

Conference Location

  • England