Construction and validation of the chronic acquired polyneuropathy patient-reported index (CAP-PRI): A disease-specific, health-related quality-of-life instrument.

Published

Journal Article

INTRODUCTION: Generic health-related quality-of-life (HRQOL) patient-reported outcome measures have been used in patients with chronic immune-mediated polyneuropathies. We have created a disease-specific HRQOL instrument. METHODS: The chronic acquired polyneuropathy patient-reported index (CAP-PRI) was developed and validated in multiple steps. Items were initially generated through patient and specialist input. The performance of the preliminary 20 items was analyzed via a prospective, 5-center study involving chronic immune-mediated polyneuropathy patients. RESULTS: Data analysis suggested modification to a 15-item scale with 3 response categories rather than 5. The final CAP-PRI was validated in another prospective, 5-center study. The CAP-PRI appeared to be a unidimensional outcome measure that fit the Rasch model in our multicenter cohort. It correlated appropriately with outcome measures commonly used in this patient population. CONCLUSIONS: The CAP-PRI is a simple disease-specific HRQOL measure that appears to be useful for clinical care and possibly also for clinical trials. Muscle Nerve 54: 9-17, 2016.

Full Text

Duke Authors

Cited Authors

  • Gwathmey, KG; Conaway, MR; Sadjadi, R; Joshi, A; Barnett, C; Bril, V; Ng, E; David, W; Gable, K; Guptill, JT; Hobson-Webb, LD; Dineen, J; Hehir, M; Brannagan, TH; Byun, E; Adler, M; Burns, TM

Published Date

  • June 2016

Published In

Volume / Issue

  • 54 / 1

Start / End Page

  • 9 - 17

PubMed ID

  • 26600438

Pubmed Central ID

  • 26600438

Electronic International Standard Serial Number (EISSN)

  • 1097-4598

Digital Object Identifier (DOI)

  • 10.1002/mus.24985

Language

  • eng

Conference Location

  • United States