Ectopic Expression of Retrotransposon-Derived PEG11/RTL1 Contributes to the Callipyge Muscular Hypertrophy.

Published online

Journal Article

The callipyge phenotype is an ovine muscular hypertrophy characterized by polar overdominance: only heterozygous +Mat/CLPGPat animals receiving the CLPG mutation from their father express the phenotype. +Mat/CLPGPat animals are characterized by postnatal, ectopic expression of Delta-like 1 homologue (DLK1) and Paternally expressed gene 11/Retrotransposon-like 1 (PEG11/RTL1) proteins in skeletal muscle. We showed previously in transgenic mice that ectopic expression of DLK1 alone induces a muscular hypertrophy, hence demonstrating a role for DLK1 in determining the callipyge hypertrophy. We herein describe newly generated transgenic mice that ectopically express PEG11 in skeletal muscle, and show that they also exhibit a muscular hypertrophy phenotype. Our data suggest that both DLK1 and PEG11 act together in causing the muscular hypertrophy of callipyge sheep.

Full Text

Duke Authors

Cited Authors

  • Xu, X; Ectors, F; Davis, EE; Pirottin, D; Cheng, H; Farnir, F; Hadfield, T; Cockett, N; Charlier, C; Georges, M; Takeda, H

Published Date

  • 2015

Published In

Volume / Issue

  • 10 / 10

Start / End Page

  • e0140594 -

PubMed ID

  • 26474044

Pubmed Central ID

  • 26474044

Electronic International Standard Serial Number (EISSN)

  • 1932-6203

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0140594

Language

  • eng

Conference Location

  • United States