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Voriconazole therapeutic drug monitoring

Publication ,  Journal Article
Hoy, Z; Weinberg, GA; Krysan, DJ
Published in: Journal of the Pediatric Infectious Diseases Society
September 1, 2014

A 2-year-old boy being treated for acute lymphoblastic leukemia developed confusion and was found to have a mass on cranial imaging.Aneurosurgical biopsy revealed an aspergilloma. Intravenous (iv) voriconazole is administered at 8 mg/kg per dose twice daily. After 10 days of therapy, 2 voriconazole peak concentrations from central venous catheter samples drawn 1 hour after infusion were 10.8 and 12.2 μg/mL. After dose reduction to 6 mg/kg per dose iv twice daily, peripheral vein trough concentration was 0.3 μg/mL. After increasing the dose to 10 mg/kg per dose iv twice daily, a subsequent trough concentration is 2.0 μg/mL. The Pediatric Infectious DiseasesConsultant is asked (1) howto interpret the variability of serum voriconazole concentrations and (2) when (and how) to check subsequent concentrations.

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Published In

Journal of the Pediatric Infectious Diseases Society

DOI

EISSN

2048-7207

ISSN

2048-7193

Publication Date

September 1, 2014

Volume

3

Issue

3

Start / End Page

270 / 271
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hoy, Z., Weinberg, G. A., & Krysan, D. J. (2014). Voriconazole therapeutic drug monitoring. Journal of the Pediatric Infectious Diseases Society, 3(3), 270–271. https://doi.org/10.1093/jpids/piu019
Hoy, Z., G. A. Weinberg, and D. J. Krysan. “Voriconazole therapeutic drug monitoring.” Journal of the Pediatric Infectious Diseases Society 3, no. 3 (September 1, 2014): 270–71. https://doi.org/10.1093/jpids/piu019.
Hoy Z, Weinberg GA, Krysan DJ. Voriconazole therapeutic drug monitoring. Journal of the Pediatric Infectious Diseases Society. 2014 Sep 1;3(3):270–1.
Hoy, Z., et al. “Voriconazole therapeutic drug monitoring.” Journal of the Pediatric Infectious Diseases Society, vol. 3, no. 3, Sept. 2014, pp. 270–71. Scopus, doi:10.1093/jpids/piu019.
Hoy Z, Weinberg GA, Krysan DJ. Voriconazole therapeutic drug monitoring. Journal of the Pediatric Infectious Diseases Society. 2014 Sep 1;3(3):270–271.
Journal cover image

Published In

Journal of the Pediatric Infectious Diseases Society

DOI

EISSN

2048-7207

ISSN

2048-7193

Publication Date

September 1, 2014

Volume

3

Issue

3

Start / End Page

270 / 271