Enhanced Immune Responses to HIV-1 Envelope Elicited by a Vaccine Regimen Consisting of Priming with Newcastle Disease Virus Expressing HIV gp160 and Boosting with gp120 and SOSIP gp140 Proteins.

Journal Article

Newcastle disease virus (NDV) expressing HIV-1 BaL gp160 was evaluated either alone or with monomeric BaL gp120 and BaL SOSIP gp140 protein in a prime-boost combination in guinea pigs to enhance envelope (Env)-specific humoral and mucosal immune responses. We showed that a regimen consisting of an NDV prime followed by a protein boost elicited stronger serum and mucosal Th-1-biased IgG responses and neutralizing antibody responses than NDV-only immunizations. Additionally, these responses were higher after the gp120 than after the SOSIP gp140 protein boost.

Full Text

Published version (via Digital Object Identifier)

Duke Authors

Cited Authors

Khattar, SK; DeVico, AL; LaBranche, CC; Panda, A; Montefiori, DC; Samal, SK

Published Date

February 2016

Published In

Journal of Virology

Volume / Issue

90 / 3

Start / End Page

1682 - 1686

PubMed ID

26581986

Electronic International Standard Serial Number (EISSN)

1098-5514

International Standard Serial Number (ISSN)

0022-538X

Digital Object Identifier (DOI)

10.1128/jvi.02847-15

Scholars@Duke