Enhanced Immune Responses to HIV-1 Envelope Elicited by a Vaccine Regimen Consisting of Priming with Newcastle Disease Virus Expressing HIV gp160 and Boosting with gp120 and SOSIP gp140 Proteins.
Journal Article (Journal Article)
Newcastle disease virus (NDV) expressing HIV-1 BaL gp160 was evaluated either alone or with monomeric BaL gp120 and BaL SOSIP gp140 protein in a prime-boost combination in guinea pigs to enhance envelope (Env)-specific humoral and mucosal immune responses. We showed that a regimen consisting of an NDV prime followed by a protein boost elicited stronger serum and mucosal Th-1-biased IgG responses and neutralizing antibody responses than NDV-only immunizations. Additionally, these responses were higher after the gp120 than after the SOSIP gp140 protein boost.
Full Text
Duke Authors
Cited Authors
- Khattar, SK; DeVico, AL; LaBranche, CC; Panda, A; Montefiori, DC; Samal, SK
Published Date
- February 1, 2016
Published In
Volume / Issue
- 90 / 3
Start / End Page
- 1682 - 1686
PubMed ID
- 26581986
Pubmed Central ID
- PMC4719621
Electronic International Standard Serial Number (EISSN)
- 1098-5514
Digital Object Identifier (DOI)
- 10.1128/JVI.02847-15
Language
- eng
Conference Location
- United States