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Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer.

Publication ,  Journal Article
Peng, J; Hamanishi, J; Matsumura, N; Abiko, K; Murat, K; Baba, T; Yamaguchi, K; Horikawa, N; Hosoe, Y; Murphy, SK; Konishi, I; Mandai, M
Published in: Cancer Res
December 1, 2015

Emerging evidence has highlighted the host immune system in modulating the patient response to chemotherapy, but the mechanism of this modulation remains unclear. The aim of this study was to analyze the effect of chemotherapy on antitumor immunity in the tumor microenvironment of ovarian cancer. Treatment of ovarian cancer cell lines with various chemotherapeutic agents resulted in upregulated expression of MHC class I and programmed cell death 1 ligand 1 (PD-L1) in a NF-κB-dependent manner and suppression of antigen-specific T-cell function in vitro. In a mouse model of ovarian cancer, treatment with paclitaxel increased CD8(+) T-cell infiltration into the tumor site, upregulated PD-L1 expression, and activated NF-κB signaling. In particular, tumor-bearing mice treated with a combination of paclitaxel and a PD-L1/PD-1 signal blockade survived longer than mice treated with paclitaxel alone. In summary, we found that chemotherapy induces local immune suppression in ovarian cancer through NF-κB-mediated PD-L1 upregulation. Thus, a combination of chemotherapy and immunotherapy targeting the PD-L1/PD-1 signaling axis may improve the antitumor response and offers a promising new treatment modality against ovarian cancer.

Duke Scholars

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Published In

Cancer Res

DOI

EISSN

1538-7445

Publication Date

December 1, 2015

Volume

75

Issue

23

Start / End Page

5034 / 5045

Location

United States

Related Subject Headings

  • Xenograft Model Antitumor Assays
  • Tumor Microenvironment
  • Transcriptome
  • Taxoids
  • Programmed Cell Death 1 Receptor
  • Ovarian Neoplasms
  • Organoplatinum Compounds
  • Oncology & Carcinogenesis
  • NF-kappa B
  • Mice
 

Citation

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Peng, J., Hamanishi, J., Matsumura, N., Abiko, K., Murat, K., Baba, T., … Mandai, M. (2015). Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer. Cancer Res, 75(23), 5034–5045. https://doi.org/10.1158/0008-5472.CAN-14-3098
Peng, Jin, Junzo Hamanishi, Noriomi Matsumura, Kaoru Abiko, Kumuruz Murat, Tsukasa Baba, Ken Yamaguchi, et al. “Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer.Cancer Res 75, no. 23 (December 1, 2015): 5034–45. https://doi.org/10.1158/0008-5472.CAN-14-3098.
Peng, Jin, et al. “Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer.Cancer Res, vol. 75, no. 23, Dec. 2015, pp. 5034–45. Pubmed, doi:10.1158/0008-5472.CAN-14-3098.
Peng J, Hamanishi J, Matsumura N, Abiko K, Murat K, Baba T, Yamaguchi K, Horikawa N, Hosoe Y, Murphy SK, Konishi I, Mandai M. Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer. Cancer Res. 2015 Dec 1;75(23):5034–5045.

Published In

Cancer Res

DOI

EISSN

1538-7445

Publication Date

December 1, 2015

Volume

75

Issue

23

Start / End Page

5034 / 5045

Location

United States

Related Subject Headings

  • Xenograft Model Antitumor Assays
  • Tumor Microenvironment
  • Transcriptome
  • Taxoids
  • Programmed Cell Death 1 Receptor
  • Ovarian Neoplasms
  • Organoplatinum Compounds
  • Oncology & Carcinogenesis
  • NF-kappa B
  • Mice