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Genetic Moderation of Stress Effects on Corticolimbic Circuitry.

Publication ,  Journal Article
Bogdan, R; Pagliaccio, D; Baranger, DA; Hariri, AR
Published in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
January 2016

Stress exposure is associated with individual differences in corticolimbic structure and function that often mirror patterns observed in psychopathology. Gene x environment interaction research suggests that genetic variation moderates the impact of stress on risk for psychopathology. On the basis of these findings, imaging genetics, which attempts to link variability in DNA sequence and structure to neural phenotypes, has begun to incorporate measures of the environment. This research paradigm, known as imaging gene x environment interaction (iGxE), is beginning to contribute to our understanding of the neural mechanisms through which genetic variation and stress increase psychopathology risk. Although awaiting replication, evidence suggests that genetic variation within the canonical neuroendocrine stress hormone system, the hypothalamic-pituitary-adrenal axis, contributes to variability in stress-related corticolimbic structure and function, which, in turn, confers risk for psychopathology. For iGxE research to reach its full potential it will have to address many challenges, of which we discuss: (i) small effects, (ii) measuring the environment and neural phenotypes, (iii) the absence of detailed mechanisms, and (iv) incorporating development. By actively addressing these challenges, iGxE research is poised to help identify the neural mechanisms underlying genetic and environmental associations with psychopathology.

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Published In

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

DOI

EISSN

1740-634X

ISSN

0893-133X

Publication Date

January 2016

Volume

41

Issue

1

Start / End Page

275 / 296

Related Subject Headings

  • Stress, Psychological
  • Psychiatry
  • Pituitary-Adrenal System
  • Nerve Net
  • Limbic System
  • Individuality
  • Hypothalamo-Hypophyseal System
  • Humans
  • Gene-Environment Interaction
  • Cerebral Cortex
 

Citation

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Bogdan, R., Pagliaccio, D., Baranger, D. A., & Hariri, A. R. (2016). Genetic Moderation of Stress Effects on Corticolimbic Circuitry. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 41(1), 275–296. https://doi.org/10.1038/npp.2015.216
Bogdan, Ryan, David Pagliaccio, David Aa Baranger, and Ahmad R. Hariri. “Genetic Moderation of Stress Effects on Corticolimbic Circuitry.Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 41, no. 1 (January 2016): 275–96. https://doi.org/10.1038/npp.2015.216.
Bogdan R, Pagliaccio D, Baranger DA, Hariri AR. Genetic Moderation of Stress Effects on Corticolimbic Circuitry. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2016 Jan;41(1):275–96.
Bogdan, Ryan, et al. “Genetic Moderation of Stress Effects on Corticolimbic Circuitry.Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 41, no. 1, Jan. 2016, pp. 275–96. Epmc, doi:10.1038/npp.2015.216.
Bogdan R, Pagliaccio D, Baranger DA, Hariri AR. Genetic Moderation of Stress Effects on Corticolimbic Circuitry. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2016 Jan;41(1):275–296.

Published In

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

DOI

EISSN

1740-634X

ISSN

0893-133X

Publication Date

January 2016

Volume

41

Issue

1

Start / End Page

275 / 296

Related Subject Headings

  • Stress, Psychological
  • Psychiatry
  • Pituitary-Adrenal System
  • Nerve Net
  • Limbic System
  • Individuality
  • Hypothalamo-Hypophyseal System
  • Humans
  • Gene-Environment Interaction
  • Cerebral Cortex