O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress.
Published
Journal Article
To evaluate the effect of age on the response of brains to an ischemic challenge, we subjected young and aged mice to transient forebrain ischemia, and analyzed the heat shock response and unfolded protein response, ubiquitin conjugation and SUMO conjugation, and O-linked β-N-acetylglucosamine modification of proteins (O-GlcNAcylation). The most prominent age-related difference was an inability of aged mice to activate O-GlcNAcylation. Considering many reports on the protective role of O-GlcNAcylation in various stress conditions including myocardial ischemia, this pathway could be a promising target for therapeutic intervention to improve functional recovery of aged patients following brain ischemia.
Full Text
Duke Authors
Cited Authors
- Liu, S; Sheng, H; Yu, Z; Paschen, W; Yang, W
Published Date
- February 2016
Published In
Volume / Issue
- 36 / 2
Start / End Page
- 393 - 398
PubMed ID
- 26661187
Pubmed Central ID
- 26661187
Electronic International Standard Serial Number (EISSN)
- 1559-7016
Digital Object Identifier (DOI)
- 10.1177/0271678X15608393
Language
- eng
Conference Location
- United States