O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress.

Journal Article (Journal Article)

To evaluate the effect of age on the response of brains to an ischemic challenge, we subjected young and aged mice to transient forebrain ischemia, and analyzed the heat shock response and unfolded protein response, ubiquitin conjugation and SUMO conjugation, and O-linked β-N-acetylglucosamine modification of proteins (O-GlcNAcylation). The most prominent age-related difference was an inability of aged mice to activate O-GlcNAcylation. Considering many reports on the protective role of O-GlcNAcylation in various stress conditions including myocardial ischemia, this pathway could be a promising target for therapeutic intervention to improve functional recovery of aged patients following brain ischemia.

Full Text

Duke Authors

Cited Authors

  • Liu, S; Sheng, H; Yu, Z; Paschen, W; Yang, W

Published Date

  • February 2016

Published In

Volume / Issue

  • 36 / 2

Start / End Page

  • 393 - 398

PubMed ID

  • 26661187

Pubmed Central ID

  • PMC4759674

Electronic International Standard Serial Number (EISSN)

  • 1559-7016

Digital Object Identifier (DOI)

  • 10.1177/0271678X15608393


  • eng

Conference Location

  • United States