O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress.
Publication
, Journal Article
Liu, S; Sheng, H; Yu, Z; Paschen, W; Yang, W
Published in: J Cereb Blood Flow Metab
February 2016
To evaluate the effect of age on the response of brains to an ischemic challenge, we subjected young and aged mice to transient forebrain ischemia, and analyzed the heat shock response and unfolded protein response, ubiquitin conjugation and SUMO conjugation, and O-linked β-N-acetylglucosamine modification of proteins (O-GlcNAcylation). The most prominent age-related difference was an inability of aged mice to activate O-GlcNAcylation. Considering many reports on the protective role of O-GlcNAcylation in various stress conditions including myocardial ischemia, this pathway could be a promising target for therapeutic intervention to improve functional recovery of aged patients following brain ischemia.
Duke Scholars
Published In
J Cereb Blood Flow Metab
DOI
EISSN
1559-7016
Publication Date
February 2016
Volume
36
Issue
2
Start / End Page
393 / 398
Location
United States
Related Subject Headings
- Unfolded Protein Response
- Ubiquitination
- Stroke
- Stress, Physiological
- SUMO-1 Protein
- Recovery of Function
- Psychomotor Performance
- Protein Processing, Post-Translational
- Neurology & Neurosurgery
- Myocardial Ischemia
Citation
APA
Chicago
ICMJE
MLA
NLM
Liu, S., Sheng, H., Yu, Z., Paschen, W., & Yang, W. (2016). O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress. J Cereb Blood Flow Metab, 36(2), 393–398. https://doi.org/10.1177/0271678X15608393
Liu, Shuai, Huaxin Sheng, Zhui Yu, Wulf Paschen, and Wei Yang. “O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress.” J Cereb Blood Flow Metab 36, no. 2 (February 2016): 393–98. https://doi.org/10.1177/0271678X15608393.
Liu S, Sheng H, Yu Z, Paschen W, Yang W. O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress. J Cereb Blood Flow Metab. 2016 Feb;36(2):393–8.
Liu, Shuai, et al. “O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress.” J Cereb Blood Flow Metab, vol. 36, no. 2, Feb. 2016, pp. 393–98. Pubmed, doi:10.1177/0271678X15608393.
Liu S, Sheng H, Yu Z, Paschen W, Yang W. O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress. J Cereb Blood Flow Metab. 2016 Feb;36(2):393–398.
Published In
J Cereb Blood Flow Metab
DOI
EISSN
1559-7016
Publication Date
February 2016
Volume
36
Issue
2
Start / End Page
393 / 398
Location
United States
Related Subject Headings
- Unfolded Protein Response
- Ubiquitination
- Stroke
- Stress, Physiological
- SUMO-1 Protein
- Recovery of Function
- Psychomotor Performance
- Protein Processing, Post-Translational
- Neurology & Neurosurgery
- Myocardial Ischemia