Genomic divergence and brain evolution: How regulatory DNA influences development of the cerebral cortex.

Journal Article (Journal Article;Review)

The cerebral cortex controls our most distinguishing higher cognitive functions. Human-specific gene expression differences are abundant in the cerebral cortex, yet we have only begun to understand how these variations impact brain function. This review discusses the current evidence linking non-coding regulatory DNA changes, including enhancers, with neocortical evolution. Functional interrogation using animal models reveals converging roles for our genome in key aspects of cortical development including progenitor cell cycle and neuronal signaling. New technologies, including iPS cells and organoids, offer potential alternatives to modeling evolutionary modifications in a relevant species context. Several diseases rooted in the cerebral cortex uniquely manifest in humans compared to other primates, thus highlighting the importance of understanding human brain differences. Future studies of regulatory loci, including those implicated in disease, will collectively help elucidate key cellular and genetic mechanisms underlying our distinguishing cognitive traits.

Full Text

Duke Authors

Cited Authors

  • Silver, DL

Published Date

  • February 2016

Published In

Volume / Issue

  • 38 / 2

Start / End Page

  • 162 - 171

PubMed ID

  • 26642006

Pubmed Central ID

  • PMC4718859

Electronic International Standard Serial Number (EISSN)

  • 1521-1878

Digital Object Identifier (DOI)

  • 10.1002/bies.201500108


  • eng

Conference Location

  • United States