Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management.

Journal Article (Journal Article;Review)

Drugs that target G protein-coupled receptors (GPCRs) represent the primary treatment strategy for patients with acute and chronic pain; however, there is substantial individual variability in both the efficacy and adverse effects associated with these drugs. Variability in drug responses is due, in part, to individuals' diversity in alternative splicing of pain-relevant GPCRs. G protein-coupled receptor alternative splice variants often exhibit distinct tissue distribution patterns, drug-binding properties, and signaling characteristics that may impact disease pathology as well as the extent and direction of analgesic effects. We review the importance of GPCRs and their known splice variants to the management of pain.

Full Text

Duke Authors

Cited Authors

  • Oladosu, FA; Maixner, W; Nackley, AG

Published Date

  • August 2015

Published In

Volume / Issue

  • 90 / 8

Start / End Page

  • 1135 - 1151

PubMed ID

  • 26250730

Pubmed Central ID

  • PMC5024555

Electronic International Standard Serial Number (EISSN)

  • 1942-5546

Digital Object Identifier (DOI)

  • 10.1016/j.mayocp.2015.06.010


  • eng

Conference Location

  • England