Increased perception of post-ischemic paresthesias in depressed subjects.

Journal Article (Journal Article)

A psychophysical assessment of sensory activity linked to unmyelinated and myelinated primary afferents was conducted by estimating the intensity of thermal and tactile post-ischemic paresthesias in 11 nontreated depressed subjects (Zung's index > or =50) and 19 controls. Blood flow in the dominant forearm was arrested until ischemic pain tolerance was reached. Ischemic pain and post-ischemic paresthesias were numerically rated. The duration of blood flow occlusion to the time of ischemic pain tolerance was similar in both groups. Thermal (warm/cool) and tactile (tingling) paresthesias were 96% and 57% more intense in depressed than in control subjects, respectively. Zung's depression scores were positively correlated with the tingling and thermal paresthesias. Ischemic pain intensity correlated positively with thermal paresthesias. These findings suggest that depression is associated with enhanced sensory paresthesias that are known to be predominately linked to unmyelinated afferent activity.

Full Text

Duke Authors

Cited Authors

  • Suarez-Roca, H; Piñerua-Shuhaibar, L; Morales, ME; Maixner, W

Published Date

  • September 2003

Published In

Volume / Issue

  • 55 / 3

Start / End Page

  • 253 - 257

PubMed ID

  • 12932799

Electronic International Standard Serial Number (EISSN)

  • 1879-1360

International Standard Serial Number (ISSN)

  • 0022-3999

Digital Object Identifier (DOI)

  • 10.1016/s0022-3999(02)00498-1


  • eng