Dorsal horn opiate administration attenuates the perceived intensity of noxious heat stimulation in behaving monkey.


Journal Article

In monkeys trained to detect and discriminate noxious heat stimuli, morphine microinjected into the medullary dorsal horn attenuated the perceived intensity of noxious heat in a dose- and stimulus-dependent fashion. These data demonstrate a pharmacologically specific effect of opiates on the sensory intensity component of pain at the earliest central relay pathway transmitting noxious information.

Full Text

Duke Authors

Cited Authors

  • Oliveras, JL; Maixner, W; Dubner, R; Bushnell, MC; Duncan, G; Thomas, DA; Bates, R

Published Date

  • April 23, 1986

Published In

Volume / Issue

  • 371 / 2

Start / End Page

  • 368 - 371

PubMed ID

  • 3697766

Pubmed Central ID

  • 3697766

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(86)90377-x


  • eng

Conference Location

  • Netherlands