Wide-dynamic-range dorsal horn neurons participate in the encoding process by which monkeys perceive the intensity of noxious heat stimuli.

Published

Journal Article

The role of dorsal horn wide-dynamic-range (WDR) and nociceptive-specific (NS) neurons in the encoding of the perceived intensity of noxious stimuli was determined while monkeys detected near-threshold changes in the intensity of noxious heat stimuli. Behavioral detection latencies were a reliable measure of the perceived intensity of these stimuli. There was a significant correlation between behavioral detection latency and neuronal discharge of WDR, but not NS neurons. In addition, WDR neurons exhibited greater activity on correctly detected vs non-detected trials, whereas NS neurons did not. We conclude that WDR neurons are involved in the encoding process by which monkeys perceive the intensity of noxious heat stimuli near detection threshold.

Full Text

Duke Authors

Cited Authors

  • Maixner, W; Dubner, R; Bushnell, MC; Kenshalo, DR; Oliveras, JL

Published Date

  • May 28, 1986

Published In

Volume / Issue

  • 374 / 2

Start / End Page

  • 385 - 388

PubMed ID

  • 3719344

Pubmed Central ID

  • 3719344

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(86)90435-x

Language

  • eng

Conference Location

  • Netherlands