Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron.
Published
Journal Article
Hypertension is among the most prevalent and catastrophic chronic diseases worldwide. While the efficacy of renin angiotensin system (RAS) blockade in lowering blood pressure illustrates that the RAS is broadly activated in human hypertension, the frequent failure of RAS inhibition to prevent or reverse hypertensive organ damage highlights the need for novel therapies to combat RAS-dependent hypertension. We previously discovered elevated levels of the macrophage cytokine IL-1 in the kidney in a murine model of RAS-mediated hypertension. Here we report that IL-1 receptor (IL-1R1) deficiency or blockade limits blood pressure elevation in this model by mitigating sodium reabsorption via the NKCC2 co-transporter in the nephron. In this setting, IL-1R1 activation prevents intra-renal myeloid cells from maturing into Ly6C(+)Ly6G(-) macrophages that elaborate nitric oxide, a natriuretic hormone that suppresses NKCC2 activity. By revealing how the innate immune system regulates tubular sodium transport, these experiments should lead to new immunomodulatory anti-hypertensive therapies.
Full Text
Duke Authors
Cited Authors
- Zhang, J; Rudemiller, NP; Patel, MB; Karlovich, NS; Wu, M; McDonough, AA; Griffiths, R; Sparks, MA; Jeffs, AD; Crowley, SD
Published Date
- February 9, 2016
Published In
Volume / Issue
- 23 / 2
Start / End Page
- 360 - 368
PubMed ID
- 26712462
Pubmed Central ID
- 26712462
Electronic International Standard Serial Number (EISSN)
- 1932-7420
Digital Object Identifier (DOI)
- 10.1016/j.cmet.2015.11.013
Language
- eng
Conference Location
- United States