Immunogenic Stimulus for Germline Precursors of Antibodies that Engage the Influenza Hemagglutinin Receptor-Binding Site.

Journal Article (Journal Article)

Influenza-virus antigenicity evolves to escape host immune protection. Antibody lineages within individuals evolve in turn to increase affinity and hence potency. Strategies for a "universal" influenza vaccine to elicit lineages that escape this evolutionary arms race and protect against seasonal variation and novel, pandemic viruses will require directing B cell ontogeny to focus the humoral response on conserved epitopes on the viral hemagglutinin (HA). The unmutated common ancestors (UCAs) of six distinct, broadly neutralizing antibody lineages from one individual bind the HA of a virus circulating at the time the participant was born. HAs of viruses circulating more than 5 years later no longer bind the UCAs, but mature antibodies in the lineages bind strains from the entire 18-year lifetime of the participant. The analysis shows how immunological memory shaped the response to subsequent influenza exposures and suggests that early imprinting by a suitable influenza antigen may enhance likelihood of later breadth.

Full Text

Duke Authors

Cited Authors

  • Schmidt, AG; Do, KT; McCarthy, KR; Kepler, TB; Liao, H-X; Moody, MA; Haynes, BF; Harrison, SC

Published Date

  • December 29, 2015

Published In

Volume / Issue

  • 13 / 12

Start / End Page

  • 2842 - 2850

PubMed ID

  • 26711348

Pubmed Central ID

  • PMC4698027

Electronic International Standard Serial Number (EISSN)

  • 2211-1247

Digital Object Identifier (DOI)

  • 10.1016/j.celrep.2015.11.063


  • eng

Conference Location

  • United States