Immunogenic Stimulus for Germline Precursors of Antibodies that Engage the Influenza Hemagglutinin Receptor-Binding Site.
Published
Journal Article
Influenza-virus antigenicity evolves to escape host immune protection. Antibody lineages within individuals evolve in turn to increase affinity and hence potency. Strategies for a "universal" influenza vaccine to elicit lineages that escape this evolutionary arms race and protect against seasonal variation and novel, pandemic viruses will require directing B cell ontogeny to focus the humoral response on conserved epitopes on the viral hemagglutinin (HA). The unmutated common ancestors (UCAs) of six distinct, broadly neutralizing antibody lineages from one individual bind the HA of a virus circulating at the time the participant was born. HAs of viruses circulating more than 5 years later no longer bind the UCAs, but mature antibodies in the lineages bind strains from the entire 18-year lifetime of the participant. The analysis shows how immunological memory shaped the response to subsequent influenza exposures and suggests that early imprinting by a suitable influenza antigen may enhance likelihood of later breadth.
Full Text
Duke Authors
Cited Authors
- Schmidt, AG; Do, KT; McCarthy, KR; Kepler, TB; Liao, H-X; Moody, MA; Haynes, BF; Harrison, SC
Published Date
- December 29, 2015
Published In
Volume / Issue
- 13 / 12
Start / End Page
- 2842 - 2850
PubMed ID
- 26711348
Pubmed Central ID
- 26711348
Electronic International Standard Serial Number (EISSN)
- 2211-1247
Digital Object Identifier (DOI)
- 10.1016/j.celrep.2015.11.063
Language
- eng
Conference Location
- United States