Phosphate modified analogues of 5'O-phosphorylated 2', 3'-dldeoxynucleosides: Synthesis and Anti-HIV activity
Phosphonate analogues of 5'-0-phosphoryl-2'3'-dideoxyribofuranosyl adenine, cytosine, hypoxanthine and thymine were synthesized. The hypoxanthine and thymine analogues were inactive against HIV induced cytopathy in the CEM-4 T-cell lines. The 2'3'-ddC and 2', 3'-ddA analogues were marginally active. © 1989, Taylor & Francis Group, LLC. All rights reserved.
Riggs, RM; Comber, RN; Montgomery, JA; Secrist, JA
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