Phosphate modified analogues of 5'O-phosphorylated 2', 3'-dldeoxynucleosides: Synthesis and Anti-HIV activity

Published

Journal Article

Phosphonate analogues of 5'-0-phosphoryl-2'3'-dideoxyribofuranosyl adenine, cytosine, hypoxanthine and thymine were synthesized. The hypoxanthine and thymine analogues were inactive against HIV induced cytopathy in the CEM-4 T-cell lines. The 2'3'-ddC and 2', 3'-ddA analogues were marginally active. © 1989, Taylor & Francis Group, LLC. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Riggs, RM; Comber, RN; Montgomery, JA; Secrist, JA

Published Date

  • January 1, 1989

Published In

Volume / Issue

  • 8 / 5-6

Start / End Page

  • 1119 - 1120

International Standard Serial Number (ISSN)

  • 0732-8311

Digital Object Identifier (DOI)

  • 10.1080/07328318908054303

Citation Source

  • Scopus