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Percutaneous Management of Benign Biliary Strictures with Large-Bore Catheters: Comparison between Patients with and without Orthotopic Liver Transplantation.

Publication ,  Journal Article
Ludwig, JM; Webber, GR; Knechtle, SJ; Spivey, JR; Xing, M; Kim, HS
Published in: J Vasc Interv Radiol
February 2016

PURPOSE: To prospectively evaluate stricture resolution and patency rates of benign biliary strictures treated with percutaneous large-bore catheter "stenting" in patients with and without previous orthotopic liver transplantation (OLT) and to compare treatment outcomes between these two groups. MATERIALS AND METHODS: Forty-six consecutive patients (25 with OLT) underwent percutaneous catheter placement in extrahepatic and single-site biliary stricture for 6-8 months, with progressive catheter upsizing to 18-20 F. Primary patency rate was defined as the proportion of patients without recurrent bile duct stricture during the follow-up period after successful stricture resolution. Secondary patency rate was defined as the proportion of patients with a patent bile duct at the end of follow-up after stricture resolution, including patients with stricture recurrence and successful repeat percutaneous biliary catheter treatment. RESULTS: Eleven patients terminated the protocol early, 6 as a result of treatment-related reasons in the orthotopic liver transplantation (OLT) group. Sixty-four percent of the OLT group and 86.4% of control patients successfully completed the protocol, with resolved biliary strictures (P = .1) after a median treatment time of 7 months for both groups (P = .96). During mean follow-up times of 20.3 months ± 11.8 (standard deviation) and 13.1 months ± 11.73 for OLT and non-OLT patients (P = .08), respectively, the primary/secondary patency rates were comparable between groups, at 81.25%/87.5% for OLT patients and 89.5%/100% for non-OLT patients (P = .64/P = .2). The mean time to recurrent stricture was 11.2 months ± 11.88. CONCLUSIONS: Percutaneous large-bore catheter treatment of benign, single-site biliary strictures showed a promising rate of stricture resolution, with comparable high primary and secondary patency rates in patients with and without previous OLT.

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Published In

J Vasc Interv Radiol

DOI

EISSN

1535-7732

Publication Date

February 2016

Volume

27

Issue

2

Start / End Page

219 / 225.e1

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Prospective Studies
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Liver Transplantation
  • Humans
  • Female
  • Constriction, Pathologic
  • Cholestasis
 

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Ludwig, J. M., Webber, G. R., Knechtle, S. J., Spivey, J. R., Xing, M., & Kim, H. S. (2016). Percutaneous Management of Benign Biliary Strictures with Large-Bore Catheters: Comparison between Patients with and without Orthotopic Liver Transplantation. J Vasc Interv Radiol, 27(2), 219-225.e1. https://doi.org/10.1016/j.jvir.2015.10.021
Ludwig, Johannes M., Grant R. Webber, Stuart J. Knechtle, James R. Spivey, Minzhi Xing, and Hyun S. Kim. “Percutaneous Management of Benign Biliary Strictures with Large-Bore Catheters: Comparison between Patients with and without Orthotopic Liver Transplantation.J Vasc Interv Radiol 27, no. 2 (February 2016): 219-225.e1. https://doi.org/10.1016/j.jvir.2015.10.021.
Ludwig JM, Webber GR, Knechtle SJ, Spivey JR, Xing M, Kim HS. Percutaneous Management of Benign Biliary Strictures with Large-Bore Catheters: Comparison between Patients with and without Orthotopic Liver Transplantation. J Vasc Interv Radiol. 2016 Feb;27(2):219-225.e1.
Ludwig, Johannes M., et al. “Percutaneous Management of Benign Biliary Strictures with Large-Bore Catheters: Comparison between Patients with and without Orthotopic Liver Transplantation.J Vasc Interv Radiol, vol. 27, no. 2, Feb. 2016, pp. 219-225.e1. Pubmed, doi:10.1016/j.jvir.2015.10.021.
Ludwig JM, Webber GR, Knechtle SJ, Spivey JR, Xing M, Kim HS. Percutaneous Management of Benign Biliary Strictures with Large-Bore Catheters: Comparison between Patients with and without Orthotopic Liver Transplantation. J Vasc Interv Radiol. 2016 Feb;27(2):219-225.e1.
Journal cover image

Published In

J Vasc Interv Radiol

DOI

EISSN

1535-7732

Publication Date

February 2016

Volume

27

Issue

2

Start / End Page

219 / 225.e1

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Prospective Studies
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Liver Transplantation
  • Humans
  • Female
  • Constriction, Pathologic
  • Cholestasis