Abundant gene conversion between arms of palindromes in human and ape Y chromosomes.

Published

Journal Article

Eight palindromes comprise one-quarter of the euchromatic DNA of the male-specific region of the human Y chromosome, the MSY. They contain many testis-specific genes and typically exhibit 99.97% intra-palindromic (arm-to-arm) sequence identity. This high degree of identity could be interpreted as evidence that the palindromes arose through duplication events that occurred about 100,000 years ago. Using comparative sequencing in great apes, we demonstrate here that at least six of these MSY palindromes predate the divergence of the human and chimpanzee lineages, which occurred about 5 million years ago. The arms of these palindromes must have subsequently engaged in gene conversion, driving the paired arms to evolve in concert. Indeed, analysis of MSY palindrome sequence variation in existing human populations provides evidence of recurrent arm-to-arm gene conversion in our species. We conclude that during recent evolution, an average of approximately 600 nucleotides per newborn male have undergone Y-Y gene conversion, which has had an important role in the evolution of multi-copy testis gene families in the MSY.

Full Text

Duke Authors

Cited Authors

  • Rozen, S; Skaletsky, H; Marszalek, JD; Minx, PJ; Cordum, HS; Waterston, RH; Wilson, RK; Page, DC

Published Date

  • June 2003

Published In

Volume / Issue

  • 423 / 6942

Start / End Page

  • 873 - 876

PubMed ID

  • 12815433

Pubmed Central ID

  • 12815433

Electronic International Standard Serial Number (EISSN)

  • 1476-4687

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/nature01723

Language

  • eng