Sneddon's syndrome with granulomatous leptomeningeal infiltration.


Journal Article

BACKGROUND: There is limited neuropathologic information available from cases of Sneddon's syndrome in which strokes are associated with livedo reticularis. Pathogenesis of the syndrome is controversial, although current opinion favors a coagulopathy, often with antiphospholipid antibodies. We describe a case lacking antiphospholipid antibodies but having a granulomatous infiltration of the leptomeninges. CASE DESCRIPTION: The patient presented at age 29 with stroke, livedo reticularis, essential hypertension, and Raynaud's phenomenon. Assessment uncovered no underlying disease, including absent antiphospholipid antibodies. A leptomeningeal biopsy showed granulomatous infiltration. CONCLUSIONS: The findings suggest that an inflammatory process plays a role in at least some cases of Sneddon's syndrome.

Full Text

Duke Authors

Cited Authors

  • Boortz-Marx, RL; Clark, HB; Taylor, S; Wesa, KM; Anderson, DC

Published Date

  • March 1995

Published In

Volume / Issue

  • 26 / 3

Start / End Page

  • 492 - 495

PubMed ID

  • 7886731

Pubmed Central ID

  • 7886731

International Standard Serial Number (ISSN)

  • 0039-2499

Digital Object Identifier (DOI)

  • 10.1161/01.str.26.3.492


  • eng

Conference Location

  • United States