Toll-like receptors and human disease: Lessons from single nucleotide polymorphisms


Journal Article (Review)

Toll-like receptors (TLRs), a large group of proteins which recognize various pathogen-associated molecular patterns, are critical for the normal function of the innate immune system. Following their discovery many single nucleotide polymorphisms within TLRs and components of their signaling machinery have been discovered and subsequently implicated in a wide range of human diseases including atherosclerosis, sepsis, asthma, and immunodeficiency. This review discusses the effect of genetic variation on TLR function and how they may precipitate disease. © 2012 Bentham Science Publishers.

Full Text

Duke Authors

Cited Authors

  • Lin, YT; Verma, A; Hodgkinson, CP

Published Date

  • December 3, 2012

Published In

Volume / Issue

  • 13 / 8

Start / End Page

  • 633 - 645

Electronic International Standard Serial Number (EISSN)

  • 1875-5488

International Standard Serial Number (ISSN)

  • 1389-2029

Digital Object Identifier (DOI)

  • 10.2174/138920212803759712

Citation Source

  • Scopus