Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.

Journal Article (Journal Article;Review)

Hepatitis C virus (HCV) is a global public health problem that mediates a persistent infection in nearly 200 million people. HCV is efficient in establishing chronicity due in part to the inefficiency of the host immune system in controlling and counteracting HCV-mediated evasion strategies. HCV persistence is linked to the ability of the virus to suppress the RIG-I pathway and interferon production from infected hepatocytes, thus evading innate immune defenses within the infected cell. This review describes the virus and host processes that regulate the RIG-I pathway during HCV infection. An understanding of these HCV-host interactions could lead to more effective therapies for HCV designed to reactivate the host immune response following HCV infection.

Full Text

Duke Authors

Cited Authors

  • Horner, SM; Gale, M

Published Date

  • September 2009

Published In

Volume / Issue

  • 29 / 9

Start / End Page

  • 489 - 498

PubMed ID

  • 19708811

Pubmed Central ID

  • PMC2956657

Electronic International Standard Serial Number (EISSN)

  • 1557-7465

Digital Object Identifier (DOI)

  • 10.1089/jir.2009.0063


  • eng

Conference Location

  • United States