Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
Journal Article (Journal Article;Review)
Hepatitis C virus (HCV) is a global public health problem that mediates a persistent infection in nearly 200 million people. HCV is efficient in establishing chronicity due in part to the inefficiency of the host immune system in controlling and counteracting HCV-mediated evasion strategies. HCV persistence is linked to the ability of the virus to suppress the RIG-I pathway and interferon production from infected hepatocytes, thus evading innate immune defenses within the infected cell. This review describes the virus and host processes that regulate the RIG-I pathway during HCV infection. An understanding of these HCV-host interactions could lead to more effective therapies for HCV designed to reactivate the host immune response following HCV infection.
Full Text
Duke Authors
Cited Authors
- Horner, SM; Gale, M
Published Date
- September 2009
Published In
Volume / Issue
- 29 / 9
Start / End Page
- 489 - 498
PubMed ID
- 19708811
Pubmed Central ID
- PMC2956657
Electronic International Standard Serial Number (EISSN)
- 1557-7465
Digital Object Identifier (DOI)
- 10.1089/jir.2009.0063
Language
- eng
Conference Location
- United States