Skip to main content
Journal cover image

Cocaine and beta-adrenergic receptor function in pregnant myometrium.

Publication ,  Journal Article
Wang, FL; Dombrowski, MP; Hurd, WW
Published in: Am J Obstet Gynecol
December 1996

OBJECTIVE: Our purpose was to evaluate the in vitro effect of cocaine on beta-adrenergic receptor function in pregnant human myometrium. STUDY DESIGN: Myometrium was obtained from 25 pregnant women at term who were undergoing cesarean section but who were not in labor. Membrane preparations were assayed for cyclic adenosine monophosphate production after exposure to isoproterenol, sodium fluoride, or forskolin in the presence and absence of either cocaine or benzoylecgonine, a major metabolite of cocaine. RESULTS: Cocaine inhibited isoproterenol-induced cyclic adenosine monophosphate production in concentrations as low as 10(-8) mol/L but had no effect on cyclic adenosine monophosphate production induced by sodium fluoride or forskolin. Benzoylecgonine (10(-4) mol/L) had no effect on isoproterenol-induced cyclic adenosine monophosphate production. CONCLUSION: Cocaine is a beta-adrenergic receptor antagonist in human myometrium at concentrations as low as 10(-8) mol/L. This acute effect of cocaine may result in increased uterine contractility with adrenergic stimulation, potentially leading to increased uterine activity associated with acute cocaine use.

Duke Scholars

Published In

Am J Obstet Gynecol

DOI

ISSN

0002-9378

Publication Date

December 1996

Volume

175

Issue

6

Start / End Page

1651 / 1653

Location

United States

Related Subject Headings

  • Sodium Fluoride
  • Receptors, Adrenergic, beta
  • Pregnancy
  • Osmolar Concentration
  • Obstetrics & Reproductive Medicine
  • Myometrium
  • Isoproterenol
  • In Vitro Techniques
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wang, F. L., Dombrowski, M. P., & Hurd, W. W. (1996). Cocaine and beta-adrenergic receptor function in pregnant myometrium. Am J Obstet Gynecol, 175(6), 1651–1653. https://doi.org/10.1016/s0002-9378(96)70120-5
Wang, F. L., M. P. Dombrowski, and W. W. Hurd. “Cocaine and beta-adrenergic receptor function in pregnant myometrium.Am J Obstet Gynecol 175, no. 6 (December 1996): 1651–53. https://doi.org/10.1016/s0002-9378(96)70120-5.
Wang FL, Dombrowski MP, Hurd WW. Cocaine and beta-adrenergic receptor function in pregnant myometrium. Am J Obstet Gynecol. 1996 Dec;175(6):1651–3.
Wang, F. L., et al. “Cocaine and beta-adrenergic receptor function in pregnant myometrium.Am J Obstet Gynecol, vol. 175, no. 6, Dec. 1996, pp. 1651–53. Pubmed, doi:10.1016/s0002-9378(96)70120-5.
Wang FL, Dombrowski MP, Hurd WW. Cocaine and beta-adrenergic receptor function in pregnant myometrium. Am J Obstet Gynecol. 1996 Dec;175(6):1651–1653.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

ISSN

0002-9378

Publication Date

December 1996

Volume

175

Issue

6

Start / End Page

1651 / 1653

Location

United States

Related Subject Headings

  • Sodium Fluoride
  • Receptors, Adrenergic, beta
  • Pregnancy
  • Osmolar Concentration
  • Obstetrics & Reproductive Medicine
  • Myometrium
  • Isoproterenol
  • In Vitro Techniques
  • Humans
  • Female