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Decrease in myometrial beta-adrenergic receptors with prenatal cocaine use.

Publication ,  Journal Article
Smith, YR; Dombrowski, MP; Leach, KC; Hurd, WW
Published in: Obstet Gynecol
March 1995

OBJECTIVE: To determine if cocaine use during pregnancy is associated with a reduction in the number or affinity of beta-adrenergic receptors in human myometrium. METHODS: Myometrium was obtained at cesarean delivery of five women who reported using cocaine during pregnancy and from ten controls. Saturation binding assays were performed on the myometrial membrane fractions using [125I]-cyanopindolol to determine beta-adrenergic receptor concentration and affinity. The percentages of beta 1- and beta 2-adrenergic receptors were determined in three cocaine users and four control patients by performing competition binding assays using the beta 2 antagonist ICI 118,551. Results were compared using unpaired Student t tests. RESULTS: Women who reported using cocaine during pregnancy had a significantly lower mean (+/- standard deviation) concentration of myometrial beta-adrenergic receptors than did controls (22 +/- 8 versus 52 +/- 23 fmol/mg protein, respectively). There was no difference in the receptor affinity constants between cocaine users and controls (16 +/- 2 pmol/L for both groups). The percentages of beta 1- and beta 2-adrenergic receptors in the myometrium of the cocaine-use group and control group were similar: 86 +/- 1% beta 2 in the cocaine-use group and 83 +/- 7% beta 2 in the control group. CONCLUSION: Cocaine use during pregnancy may be associated with a down-regulation of beta-adrenergic receptors in human myometrium. This could result in a decreased capacity for uterine relaxation and, consequently, a predisposition to preterm labor.

Duke Scholars

Published In

Obstet Gynecol

DOI

ISSN

0029-7844

Publication Date

March 1995

Volume

85

Issue

3

Start / End Page

357 / 360

Location

United States

Related Subject Headings

  • Substance-Related Disorders
  • Receptors, Adrenergic, beta
  • Propanolamines
  • Pregnancy Complications
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Myometrium
  • Humans
  • Female
  • Cocaine
 

Citation

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ICMJE
MLA
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Smith, Y. R., Dombrowski, M. P., Leach, K. C., & Hurd, W. W. (1995). Decrease in myometrial beta-adrenergic receptors with prenatal cocaine use. Obstet Gynecol, 85(3), 357–360. https://doi.org/10.1016/0029-7844(94)00424-C
Smith, Y. R., M. P. Dombrowski, K. C. Leach, and W. W. Hurd. “Decrease in myometrial beta-adrenergic receptors with prenatal cocaine use.Obstet Gynecol 85, no. 3 (March 1995): 357–60. https://doi.org/10.1016/0029-7844(94)00424-C.
Smith YR, Dombrowski MP, Leach KC, Hurd WW. Decrease in myometrial beta-adrenergic receptors with prenatal cocaine use. Obstet Gynecol. 1995 Mar;85(3):357–60.
Smith, Y. R., et al. “Decrease in myometrial beta-adrenergic receptors with prenatal cocaine use.Obstet Gynecol, vol. 85, no. 3, Mar. 1995, pp. 357–60. Pubmed, doi:10.1016/0029-7844(94)00424-C.
Smith YR, Dombrowski MP, Leach KC, Hurd WW. Decrease in myometrial beta-adrenergic receptors with prenatal cocaine use. Obstet Gynecol. 1995 Mar;85(3):357–360.
Journal cover image

Published In

Obstet Gynecol

DOI

ISSN

0029-7844

Publication Date

March 1995

Volume

85

Issue

3

Start / End Page

357 / 360

Location

United States

Related Subject Headings

  • Substance-Related Disorders
  • Receptors, Adrenergic, beta
  • Propanolamines
  • Pregnancy Complications
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Myometrium
  • Humans
  • Female
  • Cocaine