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Cocaine selectively inhibits beta-adrenergic receptor binding in pregnant human myometrium.

Publication ,  Journal Article
Hurd, WW; Gauvin, JM; Dombrowski, MP; Hayashi, RH
Published in: Am J Obstet Gynecol
September 1993

OBJECTIVE: This study evaluated the in vitro effects of cocaine on the binding characteristics of alpha- and beta-adrenergic receptors from pregnant human myometrium. STUDY DESIGN: By means of membrane fractions from myometrium obtained from 26 women at term undergoing cesarean section, equilibrium binding assays were performed with tritiated dihydroergocryptine for alpha-adrenergic receptors and iodine 125-cyanopindolol for beta-adrenergic receptors. Equilibrium competition curves were determined with and without cocaine. Results were compared by one-way analysis of variance. RESULTS: Cocaine inhibited beta-adrenergic receptor binding (inhibition constant = 132 mumol/L) but had little effect on alpha-adrenergic receptor binding (inhibition constant = 1.63 mmol/L). Benzoylecgonine, a stable metabolite of cocaine, had no effect on binding to either receptor. CONCLUSION: Cocaine selectively inhibits myometrial beta-adrenergic receptor binding. This may alter the contractile equilibrium of the pregnant uterus and could explain, in part, the association of cocaine abuse with premature delivery.

Duke Scholars

Published In

Am J Obstet Gynecol

DOI

ISSN

0002-9378

Publication Date

September 1993

Volume

169

Issue

3

Start / End Page

644 / 649

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Pregnancy
  • Pindolol
  • Obstetrics & Reproductive Medicine
  • Myometrium
  • Molecular Structure
  • Least-Squares Analysis
  • Isoproterenol
  • In Vitro Techniques
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hurd, W. W., Gauvin, J. M., Dombrowski, M. P., & Hayashi, R. H. (1993). Cocaine selectively inhibits beta-adrenergic receptor binding in pregnant human myometrium. Am J Obstet Gynecol, 169(3), 644–649. https://doi.org/10.1016/0002-9378(93)90637-x
Hurd, W. W., J. M. Gauvin, M. P. Dombrowski, and R. H. Hayashi. “Cocaine selectively inhibits beta-adrenergic receptor binding in pregnant human myometrium.Am J Obstet Gynecol 169, no. 3 (September 1993): 644–49. https://doi.org/10.1016/0002-9378(93)90637-x.
Hurd WW, Gauvin JM, Dombrowski MP, Hayashi RH. Cocaine selectively inhibits beta-adrenergic receptor binding in pregnant human myometrium. Am J Obstet Gynecol. 1993 Sep;169(3):644–9.
Hurd, W. W., et al. “Cocaine selectively inhibits beta-adrenergic receptor binding in pregnant human myometrium.Am J Obstet Gynecol, vol. 169, no. 3, Sept. 1993, pp. 644–49. Pubmed, doi:10.1016/0002-9378(93)90637-x.
Hurd WW, Gauvin JM, Dombrowski MP, Hayashi RH. Cocaine selectively inhibits beta-adrenergic receptor binding in pregnant human myometrium. Am J Obstet Gynecol. 1993 Sep;169(3):644–649.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

ISSN

0002-9378

Publication Date

September 1993

Volume

169

Issue

3

Start / End Page

644 / 649

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Pregnancy
  • Pindolol
  • Obstetrics & Reproductive Medicine
  • Myometrium
  • Molecular Structure
  • Least-Squares Analysis
  • Isoproterenol
  • In Vitro Techniques